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(6aR)-11-amino-N-propyl-noraporphine, a new dopamine D2 and serotonin 5-HT1A dual agonist, elicits potent antiparkinsonian action and attenuates levodopa-induced dyskinesia in a 6-OHDA-lesioned rat model of Parkinson's disease.
Zhao R, Lu W, Fang X, Guo L, Yang Z, Ye N, Zhao J, Liu Z, Jia J, Zheng L, Zhao B, Zhang A, Zhen X. Zhao R, et al. Among authors: zhao j, zhao b. Pharmacol Biochem Behav. 2014 Sep;124:204-10. doi: 10.1016/j.pbb.2014.06.011. Epub 2014 Jun 21. Pharmacol Biochem Behav. 2014. PMID: 24955866
SKF83959 is a potent allosteric modulator of sigma-1 receptor.
Guo L, Zhao J, Jin G, Zhao B, Wang G, Zhang A, Zhen X. Guo L, et al. Among authors: zhao j, zhao b. Mol Pharmacol. 2013 Mar;83(3):577-86. doi: 10.1124/mol.112.083840. Epub 2013 Jan 7. Mol Pharmacol. 2013. PMID: 23295385
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