Hawkins AR - Search Results

1

Insights into substrate binding and catalysis in bacterial type I dehydroquinase.

Maneiro M, Peón A, Lence E, Otero JM, Van Raaij MJ, Thompson P, Hawkins AR, González-Bello C. Maneiro M, et al. Among authors: hawkins ar. Biochem J. 2014 Sep 15;462(3):415-24. doi: 10.1042/BJ20140614. Biochem J. 2014. PMID: 24957267

2

Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues.

Prazeres VF, Tizón L, Otero JM, Guardado-Calvo P, Llamas-Saiz AL, van Raaij MJ, Castedo L, Lamb H, Hawkins AR, González-Bello C. Prazeres VF, et al. Among authors: hawkins ar. J Med Chem. 2010 Jan 14;53(1):191-200. doi: 10.1021/jm9010466. J Med Chem. 2010. PMID: 19911771

3

Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids.

Peón A, Otero JM, Tizón L, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Gago F, Castedo L, González-Bello C. Peón A, et al. Among authors: hawkins ar. ChemMedChem. 2010 Oct 4;5(10):1726-33. doi: 10.1002/cmdc.201000281. ChemMedChem. 2010. PMID: 20815012

4

A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors.

Tizón L, Otero JM, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Ainsa JA, Castedo L, González-Bello C. Tizón L, et al. Among authors: hawkins ar. J Med Chem. 2011 Sep 8;54(17):6063-84. doi: 10.1021/jm2006063. Epub 2011 Aug 3. J Med Chem. 2011. PMID: 21780742

5

Mechanistic basis of the inhibition of type II dehydroquinase by (2S)- and (2R)-2-benzyl-3-dehydroquinic acids.

Lence E, Tizón L, Otero JM, Peón A, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, González-Bello C. Lence E, et al. Among authors: hawkins ar. ACS Chem Biol. 2013 Mar 15;8(3):568-77. doi: 10.1021/cb300493s. Epub 2012 Dec 6. ACS Chem Biol. 2013. PMID: 23198883

6

Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases.

Coderch C, Lence E, Peón A, Lamb H, Hawkins AR, Gago F, González-Bello C. Coderch C, et al. Among authors: hawkins ar. Biochem J. 2014 Mar 15;458(3):547-57. doi: 10.1042/BJ20131103. Biochem J. 2014. PMID: 24392963

7

Exploring the water-binding pocket of the type II dehydroquinase enzyme in the structure-based design of inhibitors.

Blanco B, Sedes A, Peón A, Otero JM, van Raaij MJ, Thompson P, Hawkins AR, González-Bello C. Blanco B, et al. Among authors: hawkins ar. J Med Chem. 2014 Apr 24;57(8):3494-510. doi: 10.1021/jm500175z. Epub 2014 Apr 15. J Med Chem. 2014. PMID: 24689821

8

Irreversible covalent modification of type I dehydroquinase with a stable Schiff base.

Tizón L, Maneiro M, Peón A, Otero JM, Lence E, Poza S, van Raaij MJ, Thompson P, Hawkins AR, González-Bello C. Tizón L, et al. Among authors: hawkins ar. Org Biomol Chem. 2015 Jan 21;13(3):706-16. doi: 10.1039/c4ob01782j. Org Biomol Chem. 2015. PMID: 25370445

9

Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct.

González-Bello C, Tizón L, Lence E, Otero JM, van Raaij MJ, Martinez-Guitian M, Beceiro A, Thompson P, Hawkins AR. González-Bello C, et al. Among authors: hawkins ar. J Am Chem Soc. 2015 Jul 29;137(29):9333-43. doi: 10.1021/jacs.5b04080. Epub 2015 Jul 16. J Am Chem Soc. 2015. PMID: 26148116

10

Reducing the Flexibility of Type II Dehydroquinase for Inhibition: A Fragment-Based Approach and Molecular Dynamics Study.

Peón A, Robles A, Blanco B, Convertino M, Thompson P, Hawkins AR, Caflisch A, González-Bello C. Peón A, et al. Among authors: hawkins ar. ChemMedChem. 2017 Sep 21;12(18):1512-1524. doi: 10.1002/cmdc.201700396. Epub 2017 Sep 12. ChemMedChem. 2017. PMID: 28791799

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