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31 results

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Page 1
A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo.
Lewis ND, Patnaude LA, Pelletier J, Souza DJ, Lukas SM, King FJ, Hill JD, Stefanopoulos DE, Ryan K, Desai S, Skow D, Kauschke SG, Broermann A, Kuzmich D, Harcken C, Hickey ER, Modis LK. Lewis ND, et al. Among authors: hickey er. PLoS One. 2014 Jun 26;9(6):e100883. doi: 10.1371/journal.pone.0100883. eCollection 2014. PLoS One. 2014. PMID: 24967665 Free PMC article.
G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism.
Fryer RM, Ng KJ, Nodop Mazurek SG, Patnaude L, Skow DJ, Muthukumarana A, Gilpin KE, Dinallo RM, Kuzmich D, Lord J, Sanyal S, Yu H, Harcken C, Cerny MA, Hickey ER, Modis LK. Fryer RM, et al. Among authors: hickey er. J Pharmacol Exp Ther. 2014 Mar;348(3):421-31. doi: 10.1124/jpet.113.210005. Epub 2014 Jan 7. J Pharmacol Exp Ther. 2014. PMID: 24399854
Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists.
Horan JC, Sanyal S, Choi Y, Hill-Drzewi M, Patnaude L, Anderson S, Fogal S, Mao C, Cook BN, Gueneva-Boucheva K, Fisher MB, Hickey E, Pack E, Bannen LC, Chan DS, Mac MB, Ng SM, Wang Y, Xu W, Modis LK, Lemieux RM. Horan JC, et al. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4807-11. doi: 10.1016/j.bmcl.2014.09.003. Epub 2014 Sep 6. Bioorg Med Chem Lett. 2014. PMID: 25241927
Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists.
Horan JC, Kuzmich D, Liu P, DiSalvo D, Lord J, Mao C, Hopkins TD, Yu H, Harcken C, Betageri R, Hill-Drzewi M, Patenaude L, Patel M, Fletcher K, Terenzzio D, Linehan B, Xia H, Patel M, Studwell D, Miller C, Hickey E, Levin JI, Smith D, Kemper RA, Modis LK, Bannen LC, Chan DS, Mac MB, Ng S, Wang Y, Xu W, Lemieux RM. Horan JC, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):466-471. doi: 10.1016/j.bmcl.2015.11.090. Epub 2015 Nov 26. Bioorg Med Chem Lett. 2016. PMID: 26687487
Ligands for the tyrosine kinase p56lck SH2 domain: discovery of potent dipeptide derivatives with monocharged, nonhydrolyzable phosphate replacements.
Beaulieu PL, Cameron DR, Ferland JM, Gauthier J, Ghiro E, Gillard J, Gorys V, Poirier M, Rancourt J, Wernic D, Llinas-Brunet M, Betageri R, Cardozo M, Hickey ER, Ingraham R, Jakes S, Kabcenell A, Kirrane T, Lukas S, Patel U, Proudfoot J, Sharma R, Tong L, Moss N. Beaulieu PL, et al. Among authors: hickey er. J Med Chem. 1999 May 20;42(10):1757-66. doi: 10.1021/jm980676t. J Med Chem. 1999. PMID: 10346928
The discovery of thienopyridine analogues as potent IkappaB kinase beta inhibitors. Part II.
Wu JP, Fleck R, Brickwood J, Capolino A, Catron K, Chen Z, Cywin C, Emeigh J, Foerst M, Ginn J, Hrapchak M, Hickey E, Hao MH, Kashem M, Li J, Liu W, Morwick T, Nelson R, Marshall D, Martin L, Nemoto P, Potocki I, Liuzzi M, Peet GW, Scouten E, Stefany D, Turner M, Weldon S, Zimmitti C, Spero D, Kelly TA. Wu JP, et al. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5547-51. doi: 10.1016/j.bmcl.2009.08.054. Epub 2009 Aug 15. Bioorg Med Chem Lett. 2009. PMID: 19716697
Selective CB2 receptor agonists. Part 3: the optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model.
Bartolozzi A, Cirillo PF, Berry AK, Hickey ER, Thomson DS, Wu L, Zindell R, Albrecht C, Ceci A, Gemkow MJ, Nagaraja NV, Romig H, Sauer A, Riether D. Bartolozzi A, et al. Among authors: hickey er. Bioorg Med Chem Lett. 2015 Feb 1;25(3):587-92. doi: 10.1016/j.bmcl.2014.12.031. Epub 2014 Dec 17. Bioorg Med Chem Lett. 2015. PMID: 25575658
Discovery and characterization of the N-phenyl-N'-naphthylurea class of p38 kinase inhibitors.
Cirillo PF, Hickey ER, Moss N, Breitfelder S, Betageri R, Fadra T, Gaenzler F, Gilmore T, Goldberg DR, Kamhi V, Kirrane T, Kroe RR, Madwed J, Moriak M, Netherton M, Pargellis CA, Patel UR, Qian KC, Sharma R, Sun S, Swinamer A, Torcellini C, Takahashi H, Tsang M, Xiong Z. Cirillo PF, et al. Among authors: hickey er. Bioorg Med Chem Lett. 2009 May 1;19(9):2386-91. doi: 10.1016/j.bmcl.2009.03.104. Epub 2009 Mar 26. Bioorg Med Chem Lett. 2009. PMID: 19356929
31 results