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Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy.
Muller FL, Song W, Liu Y, Chaudhuri A, Pieke-Dahl S, Strong R, Huang TT, Epstein CJ, Roberts LJ 2nd, Csete M, Faulkner JA, Van Remmen H. Muller FL, et al. Among authors: liu y. Free Radic Biol Med. 2006 Jun 1;40(11):1993-2004. doi: 10.1016/j.freeradbiomed.2006.01.036. Epub 2006 Feb 17. Free Radic Biol Med. 2006. PMID: 16716900
Overexpression of Mn superoxide dismutase does not increase life span in mice.
Jang YC, Pérez VI, Song W, Lustgarten MS, Salmon AB, Mele J, Qi W, Liu Y, Liang H, Chaudhuri A, Ikeno Y, Epstein CJ, Van Remmen H, Richardson A. Jang YC, et al. Among authors: liu y. J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1114-25. doi: 10.1093/gerona/glp100. Epub 2009 Jul 24. J Gerontol A Biol Sci Med Sci. 2009. PMID: 19633237 Free PMC article.
MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging.
Lustgarten MS, Jang YC, Liu Y, Qi W, Qin Y, Dahia PL, Shi Y, Bhattacharya A, Muller FL, Shimizu T, Shirasawa T, Richardson A, Van Remmen H. Lustgarten MS, et al. Among authors: liu y. Aging Cell. 2011 Jun;10(3):493-505. doi: 10.1111/j.1474-9726.2011.00695.x. Epub 2011 Apr 5. Aging Cell. 2011. PMID: 21385310 Free PMC article.
Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD.
Jang YC, Liu Y, Hayworth CR, Bhattacharya A, Lustgarten MS, Muller FL, Chaudhuri A, Qi W, Li Y, Huang JY, Verdin E, Richardson A, Van Remmen H. Jang YC, et al. Among authors: liu y. Aging Cell. 2012 Oct;11(5):770-82. doi: 10.1111/j.1474-9726.2012.00843.x. Epub 2012 Aug 2. Aging Cell. 2012. PMID: 22672615 Free PMC article.
209,998 results
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