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The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis.
Miyazaki M, Miyazaki K, Chen S, Chandra V, Wagatsuma K, Agata Y, Rodewald HR, Saito R, Chang AN, Varki N, Kawamoto H, Murre C. Miyazaki M, et al. Among authors: varki n. Genes Dev. 2015 Feb 15;29(4):409-25. doi: 10.1101/gad.255331.114. Genes Dev. 2015. PMID: 25691468 Free PMC article.
The Ashwell receptor mitigates the lethal coagulopathy of sepsis.
Grewal PK, Uchiyama S, Ditto D, Varki N, Le DT, Nizet V, Marth JD. Grewal PK, et al. Among authors: varki n. Nat Med. 2008 Jun;14(6):648-55. doi: 10.1038/nm1760. Epub 2008 May 18. Nat Med. 2008. PMID: 18488037 Free PMC article.
ERK activation drives intestinal tumorigenesis in Apc(min/+) mice.
Lee SH, Hu LL, Gonzalez-Navajas J, Seo GS, Shen C, Brick J, Herdman S, Varki N, Corr M, Lee J, Raz E. Lee SH, et al. Among authors: varki n. Nat Med. 2010 Jun;16(6):665-70. doi: 10.1038/nm.2143. Epub 2010 May 9. Nat Med. 2010. PMID: 20473309 Free PMC article.
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.
Bard-Chapeau EA, Li S, Ding J, Zhang SS, Zhu HH, Princen F, Fang DD, Han T, Bailly-Maitre B, Poli V, Varki NM, Wang H, Feng GS. Bard-Chapeau EA, et al. Cancer Cell. 2011 May 17;19(5):629-39. doi: 10.1016/j.ccr.2011.03.023. Cancer Cell. 2011. PMID: 21575863 Free PMC article.
173 results