Koeplinger KA - Search Results

1

siRNA-mediated knockdown of P450 oxidoreductase in rats: a tool to reduce metabolism by CYPs and increase exposure of high clearance compounds.

Burke RS, Somasuntharam I, Rearden P, Brown D, Deshmukh SV, DiPietro MA, DiMuzio J, Eisenhandler R, Fauty SE, Gibson C, Gindy ME, Hamilton KA, Knemeyer I, Koeplinger KA, Kwon HW, Lifsted TQ, Menzel K, Patel M, Pudvah N, Rudd DJ, Seitzer J, Strapps WR, Prueksaritanont T, Thompson CD, Hochman JH, Carr BA. Burke RS, et al. Among authors: koeplinger ka. Pharm Res. 2014 Dec;31(12):3445-60. doi: 10.1007/s11095-014-1433-0. Epub 2014 Jul 1. Pharm Res. 2014. PMID: 24980206

2

Quantitation of physiological and biochemical barriers to siRNA liver delivery via lipid nanoparticle platform.

Xu Y, Ou M, Keough E, Roberts J, Koeplinger K, Lyman M, Fauty S, Carlini E, Stern M, Zhang R, Yeh S, Mahan E, Wang Y, Slaughter D, Gindy M, Raab C, Thompson C, Hochman J. Xu Y, et al. Mol Pharm. 2014 May 5;11(5):1424-34. doi: 10.1021/mp400584h. Epub 2014 Apr 1. Mol Pharm. 2014. PMID: 24588618

3

Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series.

Kuduk SD, Chang RK, Di Marco CN, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Kuduk SD, et al. Among authors: koeplinger ka. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1710-5. doi: 10.1016/j.bmcl.2011.01.094. Epub 2011 Jan 28. Bioorg Med Chem Lett. 2011. PMID: 21324684

4

Heterocyclic fused pyridone carboxylic acid M(1) positive allosteric modulators.

Kuduk SD, Di Marco CN, Chang RK, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Kuduk SD, et al. Among authors: koeplinger ka. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2533-7. doi: 10.1016/j.bmcl.2010.02.096. Epub 2010 Mar 3. Bioorg Med Chem Lett. 2010. PMID: 20303264

5

Hydroxy cycloalkyl fused pyridone carboxylic acid M(1) positive allosteric modulators.

Kuduk SD, DiPardo RM, Beshore DC, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Kuduk SD, et al. Among authors: koeplinger ka. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2538-41. doi: 10.1016/j.bmcl.2010.02.095. Epub 2010 Mar 10. Bioorg Med Chem Lett. 2010. PMID: 20346667

6

Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators.

Kuduk SD, Di Marco CN, Saffold JR, Ray WJ, Ma L, Wittmann M, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT, Beshore DC. Kuduk SD, et al. Among authors: koeplinger ka. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1417-20. doi: 10.1016/j.bmcl.2014.01.012. Epub 2014 Jan 13. Bioorg Med Chem Lett. 2014. PMID: 24485781

7

Fused heterocyclic M1 positive allosteric modulators.

Kuduk SD, Di Marco CN, Cofre V, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Kuduk SD, et al. Among authors: koeplinger ka. Bioorg Med Chem Lett. 2011 May 1;21(9):2769-72. doi: 10.1016/j.bmcl.2010.10.028. Epub 2010 Oct 16. Bioorg Med Chem Lett. 2011. PMID: 21055928

8

Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators.

Kuduk SD, Chang RK, Greshock TJ, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Kuduk SD, et al. Among authors: koeplinger ka. ACS Med Chem Lett. 2012 Oct 13;3(12):1070-4. doi: 10.1021/ml300280g. eCollection 2012 Dec 13. ACS Med Chem Lett. 2012. PMID: 24900430 Free PMC article.

9

Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators.

Yang ZQ, Shu Y, Ma L, Wittmann M, Ray WJ, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT, Kuduk SD. Yang ZQ, et al. Among authors: koeplinger ka. ACS Med Chem Lett. 2014 Feb 20;5(5):604-8. doi: 10.1021/ml500055h. eCollection 2014 May 8. ACS Med Chem Lett. 2014. PMID: 24900888 Free PMC article.

10

Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.

Kuduk SD, Chang RK, Di Marco CN, Pitts DR, Greshock TJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT, Ray WJ. Kuduk SD, et al. Among authors: koeplinger ka. J Med Chem. 2011 Jul 14;54(13):4773-80. doi: 10.1021/jm200400m. Epub 2011 Jun 17. J Med Chem. 2011. PMID: 21682298

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

49 results

Search Page

Filters