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siRNA-mediated knockdown of P450 oxidoreductase in rats: a tool to reduce metabolism by CYPs and increase exposure of high clearance compounds.
Burke RS, Somasuntharam I, Rearden P, Brown D, Deshmukh SV, DiPietro MA, DiMuzio J, Eisenhandler R, Fauty SE, Gibson C, Gindy ME, Hamilton KA, Knemeyer I, Koeplinger KA, Kwon HW, Lifsted TQ, Menzel K, Patel M, Pudvah N, Rudd DJ, Seitzer J, Strapps WR, Prueksaritanont T, Thompson CD, Hochman JH, Carr BA. Burke RS, et al. Among authors: patel m. Pharm Res. 2014 Dec;31(12):3445-60. doi: 10.1007/s11095-014-1433-0. Epub 2014 Jul 1. Pharm Res. 2014. PMID: 24980206
An in vivo evaluation of amphiphilic, biodegradable peptide copolymers as siRNA delivery agents.
Barrett SE, Abrams MT, Burke R, Carr BA, Crocker LS, Garbaccio RM, Howell BJ, Kemp EA, Kowtoniuk RA, Latham AH, Leander KR, Leone AM, Patel M, Pechenov S, Pudvah NT, Riley S, Sepp-Lorenzino L, Walsh ES, Williams JM, Colletti SL. Barrett SE, et al. Among authors: patel m. Int J Pharm. 2014 May 15;466(1-2):58-67. doi: 10.1016/j.ijpharm.2014.03.011. Epub 2014 Mar 5. Int J Pharm. 2014. PMID: 24607208
Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates.
Barrett SE, Burke RS, Abrams MT, Bason C, Busuek M, Carlini E, Carr BA, Crocker LS, Fan H, Garbaccio RM, Guidry EN, Heo JH, Howell BJ, Kemp EA, Kowtoniuk RA, Latham AH, Leone AM, Lyman M, Parmar RG, Patel M, Pechenov SY, Pei T, Pudvah NT, Raab C, Riley S, Sepp-Lorenzino L, Smith S, Soli ED, Staskiewicz S, Stern M, Truong Q, Vavrek M, Waldman JH, Walsh ES, Williams JM, Young S, Colletti SL. Barrett SE, et al. Among authors: patel m. J Control Release. 2014 Jun 10;183:124-37. doi: 10.1016/j.jconrel.2014.03.028. Epub 2014 Mar 21. J Control Release. 2014. PMID: 24657948
Novel endosomolytic poly(amido amine) polymer conjugates for systemic delivery of siRNA to hepatocytes in rodents and nonhuman primates.
Parmar RG, Poslusney M, Busuek M, Williams JM, Garbaccio R, Leander K, Walsh E, Howell B, Sepp-Lorenzino L, Riley S, Patel M, Kemp E, Latham A, Leone A, Soli E, Burke RS, Carr B, Colletti SL, Wang W. Parmar RG, et al. Among authors: patel m. Bioconjug Chem. 2014 May 21;25(5):896-906. doi: 10.1021/bc400527e. Epub 2014 May 5. Bioconjug Chem. 2014. PMID: 24742200
A transient cell-based phenotype assay for hepatitis C NS3/4A protease: application to potency determinations of a novel macrocyclic inhibitor against diverse protease sequences isolated from plasma infected with HCV.
Ludmerer SW, Graham DJ, Patel M, Gilbert K, Stahlhut M, Olsen DB. Ludmerer SW, et al. Among authors: patel m. J Virol Methods. 2008 Aug;151(2):301-307. doi: 10.1016/j.jviromet.2008.05.014. Epub 2008 Jun 25. J Virol Methods. 2008. PMID: 18582955
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