Decker M - Search Results

1

Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCB₂R selective benzimidazoles reveal unexpected intrinsic properties.

Nimczick M, Pemp D, Darras FH, Chen X, Heilmann J, Decker M. Nimczick M, et al. Among authors: decker m. Bioorg Med Chem. 2014 Aug 1;22(15):3938-46. doi: 10.1016/j.bmc.2014.06.008. Epub 2014 Jun 13. Bioorg Med Chem. 2014. PMID: 24984935

2

Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 receptor selectivity.

Wittig TW, Decker M, Lehmann J. Wittig TW, et al. Among authors: decker m. J Med Chem. 2004 Aug 12;47(17):4155-8. doi: 10.1021/jm049720x. J Med Chem. 2004. PMID: 15293986

3

Synthesis and vasorelaxant properties of hybrid molecules out of NO-donors and the beta-receptor blocking drug propranolol.

Decker M, König A, Glusa E, Lehmann J. Decker M, et al. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4995-7. doi: 10.1016/j.bmcl.2004.07.014. Bioorg Med Chem Lett. 2004. PMID: 15341967

4

Novel tricyclic quinazolinimines and related tetracyclic nitrogen bridgehead compounds as cholinesterase inhibitors with selectivity towards butyrylcholinesterase.

Decker M, Krauth F, Lehmann J. Decker M, et al. Bioorg Med Chem. 2006 Mar 15;14(6):1966-77. doi: 10.1016/j.bmc.2005.10.044. Epub 2005 Nov 11. Bioorg Med Chem. 2006. PMID: 16289855

5

Dopamine/serotonin receptor ligands. 10: SAR Studies on azecine-type dopamine receptor ligands by functional screening at human cloned D1, D2L, and D5 receptors with a microplate reader based calcium assay lead to a novel potent D1/D5 selective antagonist.

Hoefgen B, Decker M, Mohr P, Schramm AM, Rostom SA, El-Subbagh H, Schweikert PM, Rudolf DR, Kassack MU, Lehmann J. Hoefgen B, et al. Among authors: decker m. J Med Chem. 2006 Jan 26;49(2):760-9. doi: 10.1021/jm050846j. J Med Chem. 2006. PMID: 16420061

6

Dopamine/serotonin receptor ligands. 12(1): SAR studies on hexahydro-dibenz[d,g]azecines lead to 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol, the first picomolar D5-selective dopamine-receptor antagonist.

Mohr P, Decker M, Enzensperger C, Lehmann J. Mohr P, et al. Among authors: decker m. J Med Chem. 2006 Mar 23;49(6):2110-6. doi: 10.1021/jm051237e. J Med Chem. 2006. PMID: 16539400

7

Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase.

Decker M. Decker M. J Med Chem. 2006 Sep 7;49(18):5411-3. doi: 10.1021/jm060682m. J Med Chem. 2006. PMID: 16942014

8

6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors.

Schott Y, Decker M, Rommelspacher H, Lehmann J. Schott Y, et al. Among authors: decker m. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. doi: 10.1016/j.bmcl.2006.08.067. Epub 2006 Sep 1. Bioorg Med Chem Lett. 2006. PMID: 16945529

9

Agonistic and antagonistic bivalent ligands for serotonin and dopamine receptors including their transporters.

Decker M, Lehmann J. Decker M, et al. Curr Top Med Chem. 2007;7(4):347-53. doi: 10.2174/156802607779941297. Curr Top Med Chem. 2007. PMID: 17305576 Review.

10

Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties.

Decker M, Kraus B, Heilmann J. Decker M, et al. Bioorg Med Chem. 2008 Apr 15;16(8):4252-61. doi: 10.1016/j.bmc.2008.02.083. Epub 2008 Feb 29. Bioorg Med Chem. 2008. PMID: 18343673

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