Heilmann J - Search Results

1

Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCB₂R selective benzimidazoles reveal unexpected intrinsic properties.

Nimczick M, Pemp D, Darras FH, Chen X, Heilmann J, Decker M. Nimczick M, et al. Among authors: heilmann j. Bioorg Med Chem. 2014 Aug 1;22(15):3938-46. doi: 10.1016/j.bmc.2014.06.008. Epub 2014 Jun 13. Bioorg Med Chem. 2014. PMID: 24984935

2

Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.

Huang G, Kling B, Darras FH, Heilmann J, Decker M. Huang G, et al. Among authors: heilmann j. Eur J Med Chem. 2014 Jun 23;81:15-21. doi: 10.1016/j.ejmech.2014.05.002. Epub 2014 May 4. Eur J Med Chem. 2014. PMID: 24819955

3

Cyclic acyl guanidines bearing carbamate moieties allow potent and dirigible cholinesterase inhibition of either acetyl- or butyrylcholinesterase.

Darras FH, Kling B, Sawatzky E, Heilmann J, Decker M. Darras FH, et al. Among authors: heilmann j. Bioorg Med Chem. 2014 Sep 1;22(17):5020-34. doi: 10.1016/j.bmc.2014.06.010. Epub 2014 Jun 26. Bioorg Med Chem. 2014. PMID: 25059502

4

Design, synthesis and in vitro evaluation of novel uni- and bivalent ligands for the cannabinoid receptor type 1 with variation of spacer length and structure.

Huang G, Pemp D, Stadtmüller P, Nimczick M, Heilmann J, Decker M. Huang G, et al. Among authors: heilmann j. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4209-14. doi: 10.1016/j.bmcl.2014.07.038. Epub 2014 Jul 19. Bioorg Med Chem Lett. 2014. PMID: 25096297

5

Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties.

Decker M, Kraus B, Heilmann J. Decker M, et al. Among authors: heilmann j. Bioorg Med Chem. 2008 Apr 15;16(8):4252-61. doi: 10.1016/j.bmc.2008.02.083. Epub 2008 Feb 29. Bioorg Med Chem. 2008. PMID: 18343673

6

Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer.

Darras FH, Kling B, Heilmann J, Decker M. Darras FH, et al. Among authors: heilmann j. ACS Med Chem Lett. 2012 Aug 22;3(11):914-9. doi: 10.1021/ml3001825. eCollection 2012 Nov 8. ACS Med Chem Lett. 2012. PMID: 24900407 Free PMC article.

7

Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode.

Sawatzky E, Wehle S, Kling B, Wendrich J, Bringmann G, Sotriffer CA, Heilmann J, Decker M. Sawatzky E, et al. Among authors: heilmann j. J Med Chem. 2016 Mar 10;59(5):2067-82. doi: 10.1021/acs.jmedchem.5b01674. Epub 2016 Feb 17. J Med Chem. 2016. PMID: 26886849

8

Cytotoxic properties of the alkaloid rutaecarpine and its oligocyclic derivatives and chemical modifications to enhance water-solubility.

Huang G, Drakopoulos A, Saedtler M, Zou H, Meinel L, Heilmann J, Decker M. Huang G, et al. Among authors: heilmann j. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4937-4941. doi: 10.1016/j.bmcl.2017.08.045. Epub 2017 Aug 24. Bioorg Med Chem Lett. 2017. PMID: 28958621

9

Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.

Chen X, Zenger K, Lupp A, Kling B, Heilmann J, Fleck C, Kraus B, Decker M. Chen X, et al. Among authors: heilmann j. J Med Chem. 2012 Jun 14;55(11):5231-42. doi: 10.1021/jm300246n. Epub 2012 May 24. J Med Chem. 2012. PMID: 22624880

10

Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins.

Huang G, Schramm S, Heilmann J, Biedermann D, Křen V, Decker M. Huang G, et al. Among authors: heilmann j. Beilstein J Org Chem. 2016 Apr 8;12:662-9. doi: 10.3762/bjoc.12.66. eCollection 2016. Beilstein J Org Chem. 2016. PMID: 27340458 Free PMC article.

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