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Page 1
Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease.
Lin TT, Norris K, Heppel NH, Pratt G, Allan JM, Allsup DJ, Bailey J, Cawkwell L, Hills R, Grimstead JW, Jones RE, Britt-Compton B, Fegan C, Baird DM, Pepper C. Lin TT, et al. Among authors: heppel nh. Br J Haematol. 2014 Oct;167(2):214-23. doi: 10.1111/bjh.13023. Epub 2014 Jul 3. Br J Haematol. 2014. PMID: 24990087 Free article.
Telomere length is a critical determinant for survival in multiple myeloma.
Hyatt S, Jones RE, Heppel NH, Grimstead JW, Fegan C, Jackson GH, Hills R, Allan JM, Pratt G, Pepper C, Baird DM. Hyatt S, et al. Among authors: heppel nh. Br J Haematol. 2017 Jul;178(1):94-98. doi: 10.1111/bjh.14643. Epub 2017 Mar 24. Br J Haematol. 2017. PMID: 28342200 Free article.
Telomere length is an independent prognostic marker in MDS but not in de novo AML.
Williams J, Heppel NH, Britt-Compton B, Grimstead JW, Jones RE, Tauro S, Bowen DT, Knapper S, Groves M, Hills RK, Pepper C, Baird DM, Fegan C. Williams J, et al. Among authors: heppel nh. Br J Haematol. 2017 Jul;178(2):240-249. doi: 10.1111/bjh.14666. Epub 2017 May 9. Br J Haematol. 2017. PMID: 28486748 Free article.
Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: data from the UK LRF CLL4 trial.
Strefford JC, Kadalayil L, Forster J, Rose-Zerilli MJ, Parker A, Lin TT, Heppel N, Norris K, Gardiner A, Davies Z, Gonzalez de Castro D, Else M, Steele AJ, Parker H, Stankovic T, Pepper C, Fegan C, Baird D, Collins A, Catovsky D, Oscier DG. Strefford JC, et al. Leukemia. 2015 Dec;29(12):2411-4. doi: 10.1038/leu.2015.217. Epub 2015 Aug 10. Leukemia. 2015. PMID: 26256637 Free PMC article. No abstract available.
Escape from telomere-driven crisis is DNA ligase III dependent.
Jones RE, Oh S, Grimstead JW, Zimbric J, Roger L, Heppel NH, Ashelford KE, Liddiard K, Hendrickson EA, Baird DM. Jones RE, et al. Among authors: heppel nh. Cell Rep. 2014 Aug 21;8(4):1063-76. doi: 10.1016/j.celrep.2014.07.007. Epub 2014 Aug 7. Cell Rep. 2014. PMID: 25127141 Free article.