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Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q. Zheng X, et al. Among authors: gygi sp. Genes Dev. 2014 Jul 1;28(13):1429-44. doi: 10.1101/gad.242131.114. Genes Dev. 2014. PMID: 24990963 Free PMC article.
Phosphoproteome analysis of Drosophila melanogaster embryos.
Zhai B, Villén J, Beausoleil SA, Mintseris J, Gygi SP. Zhai B, et al. Among authors: gygi sp. J Proteome Res. 2008 Apr;7(4):1675-82. doi: 10.1021/pr700696a. Epub 2008 Mar 8. J Proteome Res. 2008. PMID: 18327897 Free PMC article.
TAK1 is an essential regulator of BMP signalling in cartilage.
Shim JH, Greenblatt MB, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LH. Shim JH, et al. EMBO J. 2009 Jul 22;28(14):2028-41. doi: 10.1038/emboj.2009.162. Epub 2009 Jun 18. EMBO J. 2009. PMID: 19536134 Free PMC article.
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice.
Greenblatt MB, Shim JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Arthur S, Xie M, Schneider MD, Zhai B, Gygi S, Davis R, Glimcher LH. Greenblatt MB, et al. J Clin Invest. 2010 Jul;120(7):2457-73. doi: 10.1172/JCI42285. Epub 2010 Jun 14. J Clin Invest. 2010. PMID: 20551513 Free PMC article.
Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W. Gao D, et al. Among authors: gygi sp. Mol Cell. 2010 Sep 10;39(5):797-808. doi: 10.1016/j.molcel.2010.08.016. Mol Cell. 2010. PMID: 20832730 Free PMC article.
763 results