Sacino AN - Search Results

1

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.

Sacino AN, Brooks M, Thomas MA, McKinney AB, Lee S, Regenhardt RW, McGarvey NH, Ayers JI, Notterpek L, Borchelt DR, Golde TE, Giasson BI. Sacino AN, et al. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10732-7. doi: 10.1073/pnas.1321785111. Epub 2014 Jul 7. Proc Natl Acad Sci U S A. 2014. PMID: 25002524 Free PMC article.

2

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein.

Sacino AN, Brooks M, McGarvey NH, McKinney AB, Thomas MA, Levites Y, Ran Y, Golde TE, Giasson BI. Sacino AN, et al. Acta Neuropathol Commun. 2013 Jul 17;1:38. doi: 10.1186/2051-5960-1-38. Acta Neuropathol Commun. 2013. PMID: 24252149 Free PMC article.

3

Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker.

Sacino AN, Brooks M, McKinney AB, Thomas MA, Shaw G, Golde TE, Giasson BI. Sacino AN, et al. J Neurosci. 2014 Sep 10;34(37):12368-78. doi: 10.1523/JNEUROSCI.2102-14.2014. J Neurosci. 2014. PMID: 25209277 Free PMC article.

4

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice.

Rutherford NJ, Sacino AN, Brooks M, Ceballos-Diaz C, Ladd TB, Howard JK, Golde TE, Giasson BI. Rutherford NJ, et al. Among authors: sacino an. Mol Neurodegener. 2015 Jul 30;10:32. doi: 10.1186/s13024-015-0029-4. Mol Neurodegener. 2015. PMID: 26223783 Free PMC article.

5

Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology.

Sacino AN, Ayers JI, Brooks MM, Chakrabarty P, Hudson VJ 3rd, Howard JK, Golde TE, Giasson BI, Borchelt DR. Sacino AN, et al. Acta Neuropathol. 2016 Jan;131(1):151-4. doi: 10.1007/s00401-015-1505-1. Epub 2015 Nov 5. Acta Neuropathol. 2016. PMID: 26541429 Free PMC article. No abstract available.

6

Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration.

Sorrentino ZA, Xia Y, Funk C, Riffe CJ, Rutherford NJ, Ceballos Diaz C, Sacino AN, Price ND, Golde TE, Giasson BI, Chakrabarty P. Sorrentino ZA, et al. Among authors: sacino an. Neurobiol Dis. 2018 Dec;120:98-106. doi: 10.1016/j.nbd.2018.09.005. Epub 2018 Sep 6. Neurobiol Dis. 2018. PMID: 30195075 Free PMC article.

7

Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils.

Dhillon JS, Trejo-Lopez JA, Riffe C, Levites Y, Sacino AN, Borchelt DR, Yachnis AY, Giasson BI. Dhillon JS, et al. Among authors: sacino an. Acta Neuropathol Commun. 2019 May 20;7(1):80. doi: 10.1186/s40478-019-0733-3. Acta Neuropathol Commun. 2019. PMID: 31109378 Free PMC article.

8

Does a prion-like mechanism play a major role in the apparent spread of α-synuclein pathology?

Sacino AN, Giasson BI. Sacino AN, et al. Alzheimers Res Ther. 2012 Dec 17;4(6):48. doi: 10.1186/alzrt151. eCollection 2012. Alzheimers Res Ther. 2012. PMID: 23245350 Free PMC article. Review.

9

Conformational templating of α-synuclein aggregates in neuronal-glial cultures.

Sacino AN, Thomas MA, Ceballos-Diaz C, Cruz PE, Rosario AM, Lewis J, Giasson BI, Golde TE. Sacino AN, et al. Mol Neurodegener. 2013 May 28;8:17. doi: 10.1186/1750-1326-8-17. Mol Neurodegener. 2013. PMID: 23714769 Free PMC article.

10

Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice.

Sacino AN, Brooks M, Thomas MA, McKinney AB, McGarvey NH, Rutherford NJ, Ceballos-Diaz C, Robertson J, Golde TE, Giasson BI. Sacino AN, et al. Acta Neuropathol. 2014 May;127(5):645-65. doi: 10.1007/s00401-014-1268-0. Acta Neuropathol. 2014. PMID: 24659240 Free PMC article.

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