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Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine.
Isayev O, Rausch V, Bauer N, Liu L, Fan P, Zhang Y, Gladkich J, Nwaeburu CC, Mattern J, Mollenhauer M, Rückert F, Zach S, Haberkorn U, Gross W, Schönsiegel F, Bazhin AV, Herr I. Isayev O, et al. Among authors: liu l. Oncotarget. 2014 Jul 15;5(13):5177-89. doi: 10.18632/oncotarget.2120. Oncotarget. 2014. PMID: 25015789 Free PMC article.
Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential.
Salnikov AV, Liu L, Platen M, Gladkich J, Salnikova O, Ryschich E, Mattern J, Moldenhauer G, Werner J, Schemmer P, Büchler MW, Herr I. Salnikov AV, et al. Among authors: liu l. PLoS One. 2012;7(9):e46391. doi: 10.1371/journal.pone.0046391. Epub 2012 Sep 26. PLoS One. 2012. PMID: 23050024 Free PMC article.
Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication.
Forster T, Rausch V, Zhang Y, Isayev O, Heilmann K, Schoensiegel F, Liu L, Nessling M, Richter K, Labsch S, Nwaeburu CC, Mattern J, Gladkich J, Giese N, Werner J, Schemmer P, Gross W, Gebhard MM, Gerhauser C, Schaefer M, Herr I. Forster T, et al. Among authors: liu l. Oncotarget. 2014 Mar 30;5(6):1621-34. doi: 10.18632/oncotarget.1764. Oncotarget. 2014. PMID: 24742583 Free PMC article.
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