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Epigallocatechin-3-gallate and related phenol compounds redirect the amyloidogenic aggregation pathway of ataxin-3 towards non-toxic aggregates and prevent toxicity in neural cells and Caenorhabditis elegans animal model.
Visentin C, Pellistri F, Natalello A, Vertemara J, Bonanomi M, Gatta E, Penco A, Relini A, De Gioia L, Airoldi C, Regonesi ME, Tortora P. Visentin C, et al. Hum Mol Genet. 2017 Sep 1;26(17):3271-3284. doi: 10.1093/hmg/ddx211. Hum Mol Genet. 2017. PMID: 28633380
Multi-eGO: An in silico lens to look into protein aggregation kinetics at atomic resolution.
Scalone E, Broggini L, Visentin C, Erba D, Bačić Toplek F, Peqini K, Pellegrino S, Ricagno S, Paissoni C, Camilloni C. Scalone E, et al. Among authors: visentin c. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2203181119. doi: 10.1073/pnas.2203181119. Epub 2022 Jun 23. Proc Natl Acad Sci U S A. 2022. PMID: 35737839 Free PMC article.
Biochemical and biophysical comparison of human and mouse beta-2 microglobulin reveals the molecular determinants of low amyloid propensity.
Achour A, Broggini L, Han X, Sun R, Santambrogio C, Buratto J, Visentin C, Barbiroli A, De Luca CMG, Sormanni P, Moda F, De Simone A, Sandalova T, Grandori R, Camilloni C, Ricagno S. Achour A, et al. Among authors: visentin c. FEBS J. 2020 Feb;287(3):546-560. doi: 10.1111/febs.15046. Epub 2019 Aug 28. FEBS J. 2020. PMID: 31420997 Free article.
72 results