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Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation.
Doi K, Li R, Sung SS, Wu H, Liu Y, Manieri W, Krishnegowda G, Awwad A, Dewey A, Liu X, Amin S, Cheng C, Qin Y, Schonbrunn E, Daughdrill G, Loughran TP Jr, Sebti S, Wang HG. Doi K, et al. Among authors: sung ss. J Biol Chem. 2012 Mar 23;287(13):10224-10235. doi: 10.1074/jbc.M111.334532. Epub 2012 Feb 6. J Biol Chem. 2012. PMID: 22311987 Free PMC article.
Targeting sphingosine-1-phosphate receptors in cancer.
Watters RJ, Wang HG, Sung SS, Loughran TP, Liu X. Watters RJ, et al. Among authors: sung ss. Anticancer Agents Med Chem. 2011 Nov;11(9):810-7. doi: 10.2174/187152011797655041. Anticancer Agents Med Chem. 2011. PMID: 21707490 Free PMC article. Review.
Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.
Chen L, Pernazza D, Scott LM, Lawrence HR, Ren Y, Luo Y, Wu X, Sung SS, Guida WC, Sebti SM, Lawrence NJ, Wu J. Chen L, et al. Among authors: sung ss. Biochem Pharmacol. 2010 Sep 15;80(6):801-10. doi: 10.1016/j.bcp.2010.05.019. Epub 2010 May 25. Biochem Pharmacol. 2010. PMID: 20510203 Free PMC article.
157 results