Sondek J - Search Results

1

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.

Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, Schmidt J, Gomeza J, Galés C, Fleischmann BK, Tüting T, Imhof D, Tietze D, Gütschow M, Holzgrabe U, Sondek J, Harden TK, Mohr K, Kostenis E. Schmitz AL, et al. Among authors: sondek j. Chem Biol. 2014 Jul 17;21(7):890-902. doi: 10.1016/j.chembiol.2014.06.003. Chem Biol. 2014. PMID: 25036778 Free PMC article.

2

A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q.

Singer AU, Waldo GL, Harden TK, Sondek J. Singer AU, et al. Among authors: sondek j. Nat Struct Biol. 2002 Jan;9(1):32-6. doi: 10.1038/nsb731. Nat Struct Biol. 2002. PMID: 11753430

3

The pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac.

Snyder JT, Singer AU, Wing MR, Harden TK, Sondek J. Snyder JT, et al. Among authors: sondek j. J Biol Chem. 2003 Jun 6;278(23):21099-104. doi: 10.1074/jbc.M301418200. Epub 2003 Mar 25. J Biol Chem. 2003. PMID: 12657629 Free article.

4

Direct activation of phospholipase C-epsilon by Rho.

Wing MR, Snyder JT, Sondek J, Harden TK. Wing MR, et al. Among authors: sondek j. J Biol Chem. 2003 Oct 17;278(42):41253-8. doi: 10.1074/jbc.M306904200. Epub 2003 Aug 4. J Biol Chem. 2003. PMID: 12900402 Free article.

5

RhoA activates purified phospholipase C-epsilon by a guanine nucleotide-dependent mechanism.

Seifert JP, Wing MR, Snyder JT, Gershburg S, Sondek J, Harden TK. Seifert JP, et al. Among authors: sondek j. J Biol Chem. 2004 Nov 12;279(46):47992-7. doi: 10.1074/jbc.M407111200. Epub 2004 Aug 18. J Biol Chem. 2004. PMID: 15322077 Free article.

6

Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange.

Johnston CA, Willard FS, Jezyk MR, Fredericks Z, Bodor ET, Jones MB, Blaesius R, Watts VJ, Harden TK, Sondek J, Ramer JK, Siderovski DP. Johnston CA, et al. Among authors: sondek j. Structure. 2005 Jul;13(7):1069-80. doi: 10.1016/j.str.2005.04.007. Structure. 2005. PMID: 16004878 Free PMC article.

7

Molecular cloning and characterization of PLC-eta2.

Zhou Y, Wing MR, Sondek J, Harden TK. Zhou Y, et al. Among authors: sondek j. Biochem J. 2005 Nov 1;391(Pt 3):667-76. doi: 10.1042/BJ20050839. Biochem J. 2005. PMID: 16107206 Free PMC article.

8

Regulation of phospholipase C isozymes by ras superfamily GTPases.

Harden TK, Sondek J. Harden TK, et al. Among authors: sondek j. Annu Rev Pharmacol Toxicol. 2006;46:355-79. doi: 10.1146/annurev.pharmtox.46.120604.141223. Annu Rev Pharmacol Toxicol. 2006. PMID: 16402909 Review.

9

Direct activation of purified phospholipase C epsilon by RhoA studied in reconstituted phospholipid vesicles.

Seifert JP, Snyder JT, Sondek J, Harden TK. Seifert JP, et al. Among authors: sondek j. Methods Enzymol. 2006;406:260-71. doi: 10.1016/S0076-6879(06)06019-8. Methods Enzymol. 2006. PMID: 16472663

10

Regulation of PLCbeta isoforms by Rac.

Snyder JT, Jezyk MR, Gershburg S, Harden TK, Sondek J. Snyder JT, et al. Among authors: sondek j. Methods Enzymol. 2006;406:272-80. doi: 10.1016/S0076-6879(06)06020-4. Methods Enzymol. 2006. PMID: 16472664

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