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Page 1
Discovery of azetidine based ene-amides as potent bacterial enoyl ACP reductase (FabI) inhibitors.
Takhi M, Sreenivas K, Reddy CK, Munikumar M, Praveena K, Sudheer P, Rao BN, Ramakanth G, Sivaranjani J, Mulik S, Reddy YR, Narasimha Rao K, Pallavi R, Lakshminarasimhan A, Panigrahi SK, Antony T, Abdullah I, Lee YK, Ramachandra M, Yusof R, Rahman NA, Subramanya H. Takhi M, et al. Eur J Med Chem. 2014 Sep 12;84:382-94. doi: 10.1016/j.ejmech.2014.07.036. Epub 2014 Jul 11. Eur J Med Chem. 2014. PMID: 25036796
AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei--Crystal structure, mode of action, and biological activity.
Rao KN, Lakshminarasimhan A, Joseph S, Lekshmi SU, Lau MS, Takhi M, Sreenivas K, Nathan S, Yusof R, Abd Rahman N, Ramachandra M, Antony T, Subramanya H. Rao KN, et al. Among authors: takhi m. Protein Sci. 2015 May;24(5):832-40. doi: 10.1002/pro.2655. Epub 2015 Apr 2. Protein Sci. 2015. PMID: 25644789 Free PMC article.
In vitro and in vivo antibacterial evaluation of DRF 8417, a new oxazolidinone.
Sreenivas K, Amarnath PV, Mallik A, Sarnaik H, Kumar NS, Takhi M, Trehan S, Kumar MS, Iqbal J, Rajagopalan R, Chakrabarti R. Sreenivas K, et al. Among authors: takhi m. J Antimicrob Chemother. 2007 Jul;60(1):159-61. doi: 10.1093/jac/dkm116. Epub 2007 Apr 21. J Antimicrob Chemother. 2007. PMID: 17449889