Rajavelu A - Search Results

1

Regulation of DNA methylation patterns by CK2-mediated phosphorylation of Dnmt3a.

Deplus R, Blanchon L, Rajavelu A, Boukaba A, Defrance M, Luciani J, Rothé F, Dedeurwaerder S, Denis H, Brinkman AB, Simmer F, Müller F, Bertin B, Berdasco M, Putmans P, Calonne E, Litchfield DW, de Launoit Y, Jurkowski TP, Stunnenberg HG, Bock C, Sotiriou C, Fraga MF, Esteller M, Jeltsch A, Fuks F. Deplus R, et al. Among authors: rajavelu a. Cell Rep. 2014 Aug 7;8(3):743-53. doi: 10.1016/j.celrep.2014.06.048. Epub 2014 Jul 24. Cell Rep. 2014. PMID: 25066127 Free article.

2

Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a-Dnmt3L single-chain fusion protein with increased DNA methylation activity.

Siddique AN, Nunna S, Rajavelu A, Zhang Y, Jurkowska RZ, Reinhardt R, Rots MG, Ragozin S, Jurkowski TP, Jeltsch A. Siddique AN, et al. Among authors: rajavelu a. J Mol Biol. 2013 Feb 8;425(3):479-91. doi: 10.1016/j.jmb.2012.11.038. Epub 2012 Dec 4. J Mol Biol. 2013. PMID: 23220192

3

Cooperative DNA binding and protein/DNA fiber formation increases the activity of the Dnmt3a DNA methyltransferase.

Emperle M, Rajavelu A, Reinhardt R, Jurkowska RZ, Jeltsch A. Emperle M, et al. Among authors: rajavelu a. J Biol Chem. 2014 Oct 24;289(43):29602-13. doi: 10.1074/jbc.M114.572032. Epub 2014 Aug 21. J Biol Chem. 2014. PMID: 25147181 Free PMC article.

4

The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes.

Emperle M, Dukatz M, Kunert S, Holzer K, Rajavelu A, Jurkowska RZ, Jeltsch A. Emperle M, et al. Among authors: rajavelu a. Sci Rep. 2018 Sep 5;8(1):13242. doi: 10.1038/s41598-018-31635-8. Sci Rep. 2018. PMID: 30185810 Free PMC article.

5

The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation.

Dhayalan A, Rajavelu A, Rathert P, Tamas R, Jurkowska RZ, Ragozin S, Jeltsch A. Dhayalan A, et al. Among authors: rajavelu a. J Biol Chem. 2010 Aug 20;285(34):26114-20. doi: 10.1074/jbc.M109.089433. Epub 2010 Jun 11. J Biol Chem. 2010. PMID: 20547484 Free PMC article.

6

Function and disruption of DNA methyltransferase 3a cooperative DNA binding and nucleoprotein filament formation.

Rajavelu A, Jurkowska RZ, Fritz J, Jeltsch A. Rajavelu A, et al. Nucleic Acids Res. 2012 Jan;40(2):569-80. doi: 10.1093/nar/gkr753. Epub 2011 Sep 16. Nucleic Acids Res. 2012. PMID: 21926161 Free PMC article.

7

Targeted mutagenesis results in an activation of DNA methyltransferase 1 and confirms an autoinhibitory role of its RFTS domain.

Bashtrykov P, Rajavelu A, Hackner B, Ragozin S, Carell T, Jeltsch A. Bashtrykov P, et al. Among authors: rajavelu a. Chembiochem. 2014 Mar 21;15(5):743-8. doi: 10.1002/cbic.201300740. Epub 2014 Feb 13. Chembiochem. 2014. PMID: 24532244

8

The DNMT3A R882H mutant displays altered flanking sequence preferences.

Emperle M, Rajavelu A, Kunert S, Arimondo PB, Reinhardt R, Jurkowska RZ, Jeltsch A. Emperle M, et al. Among authors: rajavelu a. Nucleic Acids Res. 2018 Apr 6;46(6):3130-3139. doi: 10.1093/nar/gky168. Nucleic Acids Res. 2018. PMID: 29518238 Free PMC article.

9

Oligomerization and binding of the Dnmt3a DNA methyltransferase to parallel DNA molecules: heterochromatic localization and role of Dnmt3L.

Jurkowska RZ, Rajavelu A, Anspach N, Urbanke C, Jankevicius G, Ragozin S, Nellen W, Jeltsch A. Jurkowska RZ, et al. Among authors: rajavelu a. J Biol Chem. 2011 Jul 8;286(27):24200-7. doi: 10.1074/jbc.M111.254987. Epub 2011 May 12. J Biol Chem. 2011. PMID: 21566127 Free PMC article.

10

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail.

Zhang Y, Jurkowska R, Soeroes S, Rajavelu A, Dhayalan A, Bock I, Rathert P, Brandt O, Reinhardt R, Fischle W, Jeltsch A. Zhang Y, et al. Among authors: rajavelu a. Nucleic Acids Res. 2010 Jul;38(13):4246-53. doi: 10.1093/nar/gkq147. Epub 2010 Mar 11. Nucleic Acids Res. 2010. PMID: 20223770 Free PMC article.

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