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Low-density lipoprotein receptor-related protein-1 mediates endocytic clearance of tissue inhibitor of metalloproteinases-1 and promotes its cytokine-like activities.
Thevenard J, Verzeaux L, Devy J, Etique N, Jeanne A, Schneider C, Hachet C, Ferracci G, David M, Martiny L, Charpentier E, Khrestchatisky M, Rivera S, Dedieu S, Emonard H. Thevenard J, et al. Among authors: david m. PLoS One. 2014 Jul 30;9(7):e103839. doi: 10.1371/journal.pone.0103839. eCollection 2014. PLoS One. 2014. PMID: 25075518 Free PMC article.
Identification and characterization of highly versatile peptide-vectors that bind non-competitively to the low-density lipoprotein receptor for in vivo targeting and delivery of small molecules and protein cargos.
David M, Lécorché P, Masse M, Faucon A, Abouzid K, Gaudin N, Varini K, Gassiot F, Ferracci G, Jacquot G, Vlieghe P, Khrestchatisky M. David M, et al. PLoS One. 2018 Feb 27;13(2):e0191052. doi: 10.1371/journal.pone.0191052. eCollection 2018. PLoS One. 2018. PMID: 29485998 Free PMC article.
LRP-1--CD44, a new cell surface complex regulating tumor cell adhesion.
Perrot G, Langlois B, Devy J, Jeanne A, Verzeaux L, Almagro S, Sartelet H, Hachet C, Schneider C, Sick E, David M, Khrestchatisky M, Emonard H, Martiny L, Dedieu S. Perrot G, et al. Among authors: david m. Mol Cell Biol. 2012 Aug;32(16):3293-307. doi: 10.1128/MCB.00228-12. Epub 2012 Jun 18. Mol Cell Biol. 2012. PMID: 22711991 Free PMC article.
Optimization and in Vivo Validation of Peptide Vectors Targeting the LDL Receptor.
Jacquot G, Lécorché P, Malcor JD, Laurencin M, Smirnova M, Varini K, Malicet C, Gassiot F, Abouzid K, Faucon A, David M, Gaudin N, Masse M, Ferracci G, Dive V, Cisternino S, Khrestchatisky M. Jacquot G, et al. Among authors: david m. Mol Pharm. 2016 Dec 5;13(12):4094-4105. doi: 10.1021/acs.molpharmaceut.6b00687. Epub 2016 Oct 11. Mol Pharm. 2016. PMID: 27656777
Target engagement and intracellular delivery of mono- and bivalent LDL receptor-binding peptide-cargo conjugates: Implications for the rational design of new targeted drug therapies.
Varini K, Lécorché P, Sonnette R, Gassiot F, Broc B, Godard M, David M, Faucon A, Abouzid K, Ferracci G, Temsamani J, Khrestchatisky M, Jacquot G. Varini K, et al. Among authors: david m. J Control Release. 2019 Nov 28;314:141-161. doi: 10.1016/j.jconrel.2019.10.033. Epub 2019 Oct 20. J Control Release. 2019. PMID: 31644939
Use of LDL receptor-targeting peptide vectors for in vitro and in vivo cargo transport across the blood-brain barrier.
Molino Y, David M, Varini K, Jabès F, Gaudin N, Fortoul A, Bakloul K, Masse M, Bernard A, Drobecq L, Lécorché P, Temsamani J, Jacquot G, Khrestchatisky M. Molino Y, et al. Among authors: david m. FASEB J. 2017 May;31(5):1807-1827. doi: 10.1096/fj.201600827R. Epub 2017 Jan 20. FASEB J. 2017. PMID: 28108572
We thus provide further evidence that LDLR is a relevant receptor for CNS drug delivery via receptor-mediated transcytosis and that the peptide vectors we developed have the potential to transport drugs, including proteins or Ab based, across the BBB.-Molino, Y., David, …
We thus provide further evidence that LDLR is a relevant receptor for CNS drug delivery via receptor-mediated transcytosis and that the pept …
[Abortion from a multidisciplinary perspective].
David M, Kuhn J, Saß AC. David M, et al. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2025 Jan;68(1):1-2. doi: 10.1007/s00103-024-03996-1. Epub 2025 Jan 14. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2025. PMID: 39808277 Free PMC article. German. No abstract available.
3,383 results