Herhaus L - Search Results

1

Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2).

Tan L, Nomanbhoy T, Gurbani D, Patricelli M, Hunter J, Geng J, Herhaus L, Zhang J, Pauls E, Ham Y, Choi HG, Xie T, Deng X, Buhrlage SJ, Sim T, Cohen P, Sapkota G, Westover KD, Gray NS. Tan L, et al. Among authors: herhaus l. J Med Chem. 2015 Jan 8;58(1):183-96. doi: 10.1021/jm500480k. Epub 2014 Jul 30. J Med Chem. 2015. PMID: 25075558 Free PMC article.

2

The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways.

Herhaus L, Sapkota GP. Herhaus L, et al. Cell Signal. 2014 Oct;26(10):2186-92. doi: 10.1016/j.cellsig.2014.06.012. Epub 2014 Jul 5. Cell Signal. 2014. PMID: 25007997 Free PMC article. Review.

3

USP11 augments TGFβ signalling by deubiquitylating ALK5.

Al-Salihi MA, Herhaus L, Macartney T, Sapkota GP. Al-Salihi MA, et al. Among authors: herhaus l. Open Biol. 2012 Jun;2(6):120063. doi: 10.1098/rsob.120063. Open Biol. 2012. PMID: 22773947 Free PMC article.

4

Regulation of the transforming growth factor β pathway by reversible ubiquitylation.

Al-Salihi MA, Herhaus L, Sapkota GP. Al-Salihi MA, et al. Among authors: herhaus l. Open Biol. 2012 May;2(5):120082. doi: 10.1098/rsob.120082. Open Biol. 2012. PMID: 22724073 Free PMC article. Review.

5

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization.

Herhaus L, Perez-Oliva AB, Cozza G, Gourlay R, Weidlich S, Campbell DG, Pinna LA, Sapkota GP. Herhaus L, et al. Sci Signal. 2015 Apr 14;8(372):ra35. doi: 10.1126/scisignal.aaa0441. Sci Signal. 2015. PMID: 25872870 Free PMC article.

6

OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3.

Herhaus L, Al-Salihi M, Macartney T, Weidlich S, Sapkota GP. Herhaus L, et al. Nat Commun. 2013;4:2519. doi: 10.1038/ncomms3519. Nat Commun. 2013. PMID: 24071738 Free PMC article.

7

Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling.

Vogt J, Dingwell KS, Herhaus L, Gourlay R, Macartney T, Campbell D, Smith JC, Sapkota GP. Vogt J, et al. Among authors: herhaus l. Open Biol. 2014 Feb 19;4(2):130210. doi: 10.1098/rsob.130210. Open Biol. 2014. PMID: 24554596 Free PMC article.

8

Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9.

Rojas-Fernandez A, Herhaus L, Macartney T, Lachaud C, Hay RT, Sapkota GP. Rojas-Fernandez A, et al. Among authors: herhaus l. Sci Rep. 2015 Apr 29;5:9811. doi: 10.1038/srep09811. Sci Rep. 2015. PMID: 25922883 Free PMC article.

9

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.

Herhaus L, Al-Salihi MA, Dingwell KS, Cummins TD, Wasmus L, Vogt J, Ewan R, Bruce D, Macartney T, Weidlich S, Smith JC, Sapkota GP. Herhaus L, et al. Open Biol. 2014 May;4(5):140065. doi: 10.1098/rsob.140065. Open Biol. 2014. PMID: 24850914 Free PMC article.

10

Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA.

Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I. Fiskin E, et al. Among authors: herhaus l. Nat Commun. 2017 Jan 13;8:14004. doi: 10.1038/ncomms14004. Nat Commun. 2017. PMID: 28084320 Free PMC article.

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