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Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability.
Blana A, Kaese S, Fortmüller L, Laakmann S, Damke D, van Bragt K, Eckstein J, Piccini I, Kirchhefer U, Nattel S, Breithardt G, Carmeliet P, Carmeliet E, Schotten U, Verheule S, Kirchhof P, Fabritz L. Blana A, et al. Among authors: eckstein j. Heart Rhythm. 2010 Dec;7(12):1862-9. doi: 10.1016/j.hrthm.2010.08.016. Epub 2010 Aug 19. Heart Rhythm. 2010. PMID: 20728579
Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice.
Kirchhof P, Marijon E, Fabritz L, Li N, Wang W, Wang T, Schulte K, Hanstein J, Schulte JS, Vogel M, Mougenot N, Laakmann S, Fortmueller L, Eckstein J, Verheule S, Kaese S, Staab A, Grote-Wessels S, Schotten U, Moubarak G, Wehrens XH, Schmitz W, Hatem S, Müller FU. Kirchhof P, et al. Among authors: eckstein j. Int J Cardiol. 2013 Jun 20;166(2):366-74. doi: 10.1016/j.ijcard.2011.10.057. Epub 2011 Nov 16. Int J Cardiol. 2013. PMID: 22093963 Free PMC article.
Rearrangement of atrial bundle architecture and consequent changes in anisotropy of conduction constitute the 3-dimensional substrate for atrial fibrillation.
Maesen B, Zeemering S, Afonso C, Eckstein J, Burton RA, van Hunnik A, Stuckey DJ, Tyler D, Maessen J, Grau V, Verheule S, Kohl P, Schotten U. Maesen B, et al. Among authors: eckstein j. Circ Arrhythm Electrophysiol. 2013 Oct;6(5):967-75. doi: 10.1161/CIRCEP.113.000050. Epub 2013 Aug 22. Circ Arrhythm Electrophysiol. 2013. PMID: 23969531
334 results