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Discovery of Potent and Orally Bioavailable Pyrimidine Amide cGAS Inhibitors via Structure-Guided Hybridization.
Cyr P, Fader LD, Burch JD, Pike KA, Sietsema DV, Boily MO, Ciblat S, Sgarioto N, Skeldon AM, Gaudreault S, Le Gros P, Dumais V, McKay DJJ, Abraham NS, Seliniotakis R, Beveridge RE. Cyr P, et al. Among authors: boily mo. ACS Med Chem Lett. 2024 Nov 25;15(12):2201-2209. doi: 10.1021/acsmedchemlett.4c00471. eCollection 2024 Dec 12. ACS Med Chem Lett. 2024. PMID: 39691514
Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria.
Ding J, Gumpena R, Boily MO, Caron A, Chong O, Cox JH, Dumais V, Gaudreault S, Graff AH, King A, Knight J, Oballa R, Surendradoss J, Tang T, Wu J, Lowther WT, Powell DA. Ding J, et al. Among authors: boily mo. ACS Med Chem Lett. 2021 May 20;12(7):1116-1123. doi: 10.1021/acsmedchemlett.1c00196. eCollection 2021 Jul 8. ACS Med Chem Lett. 2021. PMID: 34267881 Free PMC article.