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Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication.
Berger C, Romero-Brey I, Radujkovic D, Terreux R, Zayas M, Paul D, Harak C, Hoppe S, Gao M, Penin F, Lohmann V, Bartenschlager R. Berger C, et al. Among authors: zayas m. Gastroenterology. 2014 Nov;147(5):1094-105.e25. doi: 10.1053/j.gastro.2014.07.019. Epub 2014 Jul 18. Gastroenterology. 2014. PMID: 25046163 Free article.
The lipid droplet is an important organelle for hepatitis C virus production.
Miyanari Y, Atsuzawa K, Usuda N, Watashi K, Hishiki T, Zayas M, Bartenschlager R, Wakita T, Hijikata M, Shimotohno K. Miyanari Y, et al. Among authors: zayas m. Nat Cell Biol. 2007 Sep;9(9):1089-97. doi: 10.1038/ncb1631. Epub 2007 Aug 26. Nat Cell Biol. 2007. PMID: 17721513
52 results