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SET-ting the stage for DNA repair.
Jha DK, Pfister SX, Humphrey TC, Strahl BD. Jha DK, et al. Among authors: humphrey tc. Nat Struct Mol Biol. 2014 Aug;21(8):655-7. doi: 10.1038/nsmb.2866. Nat Struct Mol Biol. 2014. PMID: 25093525 No abstract available.
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
Pfister SX, Markkanen E, Jiang Y, Sarkar S, Woodcock M, Orlando G, Mavrommati I, Pai CC, Zalmas LP, Drobnitzky N, Dianov GL, Verrill C, Macaulay VM, Ying S, La Thangue NB, D'Angiolella V, Ryan AJ, Humphrey TC. Pfister SX, et al. Among authors: humphrey tc. Cancer Cell. 2015 Nov 9;28(5):557-568. doi: 10.1016/j.ccell.2015.09.015. Cancer Cell. 2015. PMID: 26602815 Free PMC article.
An essential role for dNTP homeostasis following CDK-induced replication stress.
Pai CC, Hsu KF, Durley SC, Keszthelyi A, Kearsey SE, Rallis C, Folkes LK, Deegan R, Wilkins SE, Pfister SX, De León N, Schofield CJ, Bähler J, Carr AM, Humphrey TC. Pai CC, et al. Among authors: humphrey tc. J Cell Sci. 2019 Mar 25;132(6):jcs226969. doi: 10.1242/jcs.226969. J Cell Sci. 2019. PMID: 30674555 Free PMC article.
The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast.
Blaikley EJ, Tinline-Purvis H, Kasparek TR, Marguerat S, Sarkar S, Hulme L, Hussey S, Wee BY, Deegan RS, Walker CA, Pai CC, Bähler J, Nakagawa T, Humphrey TC. Blaikley EJ, et al. Among authors: humphrey tc. Nucleic Acids Res. 2014 May;42(9):5644-56. doi: 10.1093/nar/gku190. Epub 2014 Mar 12. Nucleic Acids Res. 2014. PMID: 24623809 Free PMC article.
52 results