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Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.
Chamberlain PP, Lopez-Girona A, Miller K, Carmel G, Pagarigan B, Chie-Leon B, Rychak E, Corral LG, Ren YJ, Wang M, Riley M, Delker SL, Ito T, Ando H, Mori T, Hirano Y, Handa H, Hakoshima T, Daniel TO, Cathers BE. Chamberlain PP, et al. Among authors: riley m. Nat Struct Mol Biol. 2014 Sep;21(9):803-9. doi: 10.1038/nsmb.2874. Epub 2014 Aug 10. Nat Struct Mol Biol. 2014. PMID: 25108355
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Matyskiela ME, Lu G, Ito T, Pagarigan B, Lu CC, Miller K, Fang W, Wang NY, Nguyen D, Houston J, Carmel G, Tran T, Riley M, Nosaka L, Lander GC, Gaidarova S, Xu S, Ruchelman AL, Handa H, Carmichael J, Daniel TO, Cathers BE, Lopez-Girona A, Chamberlain PP. Matyskiela ME, et al. Among authors: riley m. Nature. 2016 Jul 14;535(7611):252-7. doi: 10.1038/nature18611. Epub 2016 Jun 22. Nature. 2016. PMID: 27338790
A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
Matyskiela ME, Zhang W, Man HW, Muller G, Khambatta G, Baculi F, Hickman M, LeBrun L, Pagarigan B, Carmel G, Lu CC, Lu G, Riley M, Satoh Y, Schafer P, Daniel TO, Carmichael J, Cathers BE, Chamberlain PP. Matyskiela ME, et al. Among authors: riley m. J Med Chem. 2018 Jan 25;61(2):535-542. doi: 10.1021/acs.jmedchem.6b01921. Epub 2017 Apr 20. J Med Chem. 2018. PMID: 28425720
SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate.
Matyskiela ME, Couto S, Zheng X, Lu G, Hui J, Stamp K, Drew C, Ren Y, Wang M, Carpenter A, Lee CW, Clayton T, Fang W, Lu CC, Riley M, Abdubek P, Blease K, Hartke J, Kumar G, Vessey R, Rolfe M, Hamann LG, Chamberlain PP. Matyskiela ME, et al. Among authors: riley m. Nat Chem Biol. 2018 Oct;14(10):981-987. doi: 10.1038/s41589-018-0129-x. Epub 2018 Sep 6. Nat Chem Biol. 2018. PMID: 30190590
Novel oxysterols activate the Hedgehog pathway and induce osteogenesis.
Stappenbeck F, Xiao W, Epperson M, Riley M, Priest A, Huang D, Nguyen K, Jung ME, Thies RS, Farouz F. Stappenbeck F, et al. Among authors: riley m. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5893-7. doi: 10.1016/j.bmcl.2012.07.073. Epub 2012 Jul 27. Bioorg Med Chem Lett. 2012. PMID: 22901899
Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers.
Monga S, Lehrich B, Delgado E, Yasaka T, Liu S, Cao C, Liu Y, Taheri M, Guan X, Koeppen H, Singh S, Liu JJ, Singh-Varma A, Krutsenko Y, Poddar M, Hitchens T, Foley L, Liang B, Rialdi A, Rai R, Patel P, Riley M, Bell A, Raeman R, Dadali T, Luke J, Guccione E, Ebrahimkhani M, Lujambio A, Chen X, Maier M, Wang Y, Broom W, Tao J. Monga S, et al. Among authors: riley m. Res Sq [Preprint]. 2024 Dec 12:rs.3.rs-5494074. doi: 10.21203/rs.3.rs-5494074/v1. Res Sq. 2024. PMID: 39711542 Free PMC article. Preprint.
Preprocedural Screening Tool to Guide Nonpulmonary Vein Trigger Testing in First-Time Atrial Fibrillation Ablation.
Oraii A, Chaumont C, Rodriguez-Queralto O, Wasiak M, Thind M, Peters CJ, Zado E, Hanumanthu BKJ, Markman TM, Hyman MC, Tschabrunn CM, Guandalini G, Enriquez A, Shivamurthy P, Kumareswaran R, Riley MP, Lin D, Schaller RD, Nazarian S, Callans DJ, Supple GE, Garcia FC, Frankel DS, Dixit S, Marchlinski FE. Oraii A, et al. Among authors: riley mp. Circ Arrhythm Electrophysiol. 2024 Dec 20:e013351. doi: 10.1161/CIRCEP.124.013351. Online ahead of print. Circ Arrhythm Electrophysiol. 2024. PMID: 39704068
1,429 results