Arnold E - Search Results

1

Advantages of crystallographic fragment screening: functional and mechanistic insights from a powerful platform for efficient drug discovery.

Patel D, Bauman JD, Arnold E. Patel D, et al. Among authors: arnold e. Prog Biophys Mol Biol. 2014 Nov-Dec;116(2-3):92-100. doi: 10.1016/j.pbiomolbio.2014.08.004. Epub 2014 Aug 10. Prog Biophys Mol Biol. 2014. PMID: 25117499 Free PMC article. Review.

2

Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors.

Das K, Lewi PJ, Hughes SH, Arnold E. Das K, et al. Among authors: arnold e. Prog Biophys Mol Biol. 2005 Jun;88(2):209-31. doi: 10.1016/j.pbiomolbio.2004.07.001. Prog Biophys Mol Biol. 2005. PMID: 15572156 Free article. Review.

3

Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097.

Das K, Sarafianos SG, Clark AD Jr, Boyer PL, Hughes SH, Arnold E. Das K, et al. Among authors: arnold e. J Mol Biol. 2007 Jan 5;365(1):77-89. doi: 10.1016/j.jmb.2006.08.097. Epub 2006 Sep 15. J Mol Biol. 2007. PMID: 17056061

4

Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase.

Fang C, Bauman JD, Das K, Remorino A, Arnold E, Hochstrasser RM. Fang C, et al. Among authors: arnold e. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1472-7. doi: 10.1073/pnas.0709320104. Epub 2007 Nov 26. Proc Natl Acad Sci U S A. 2008. PMID: 18040050 Free PMC article.

5

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations.

Das K, Bauman JD, Clark AD Jr, Frenkel YV, Lewi PJ, Shatkin AJ, Hughes SH, Arnold E. Das K, et al. Among authors: arnold e. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1466-71. doi: 10.1073/pnas.0711209105. Epub 2008 Jan 29. Proc Natl Acad Sci U S A. 2008. PMID: 18230722 Free PMC article.

6

Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design.

Bauman JD, Das K, Ho WC, Baweja M, Himmel DM, Clark AD Jr, Oren DA, Boyer PL, Hughes SH, Shatkin AJ, Arnold E. Bauman JD, et al. Among authors: arnold e. Nucleic Acids Res. 2008 Sep;36(15):5083-92. doi: 10.1093/nar/gkn464. Epub 2008 Aug 1. Nucleic Acids Res. 2008. PMID: 18676450 Free PMC article.

7

Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase.

Cullen MD, Ho WC, Bauman JD, Das K, Arnold E, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Cullen MD, et al. Among authors: arnold e. J Med Chem. 2009 Oct 22;52(20):6467-73. doi: 10.1021/jm901167t. J Med Chem. 2009. PMID: 19775161 Free PMC article.

8

Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.

Himmel DM, Maegley KA, Pauly TA, Bauman JD, Das K, Dharia C, Clark AD Jr, Ryan K, Hickey MJ, Love RA, Hughes SH, Bergqvist S, Arnold E. Himmel DM, et al. Among authors: arnold e. Structure. 2009 Dec 9;17(12):1625-1635. doi: 10.1016/j.str.2009.09.016. Structure. 2009. PMID: 20004166 Free PMC article.

9

Structural basis of HIV-1 resistance to AZT by excision.

Tu X, Das K, Han Q, Bauman JD, Clark AD Jr, Hou X, Frenkel YV, Gaffney BL, Jones RA, Boyer PL, Hughes SH, Sarafianos SG, Arnold E. Tu X, et al. Among authors: arnold e. Nat Struct Mol Biol. 2010 Oct;17(10):1202-9. doi: 10.1038/nsmb.1908. Epub 2010 Sep 19. Nat Struct Mol Biol. 2010. PMID: 20852643 Free PMC article.

10

Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.

Das K, Bauman JD, Rim AS, Dharia C, Clark AD Jr, Camarasa MJ, Balzarini J, Arnold E. Das K, et al. Among authors: arnold e. J Med Chem. 2011 Apr 28;54(8):2727-37. doi: 10.1021/jm101536x. Epub 2011 Mar 29. J Med Chem. 2011. PMID: 21446702 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

950 results

Search Page

Filters