Patel D - Search Results

1

Advantages of crystallographic fragment screening: functional and mechanistic insights from a powerful platform for efficient drug discovery.

Patel D, Bauman JD, Arnold E. Patel D, et al. Prog Biophys Mol Biol. 2014 Nov-Dec;116(2-3):92-100. doi: 10.1016/j.pbiomolbio.2014.08.004. Epub 2014 Aug 10. Prog Biophys Mol Biol. 2014. PMID: 25117499 Free PMC article. Review.

2

Fragment screening and HIV therapeutics.

Bauman JD, Patel D, Arnold E. Bauman JD, et al. Among authors: patel d. Top Curr Chem. 2012;317:181-200. doi: 10.1007/128_2011_232. Top Curr Chem. 2012. PMID: 21972022 Free PMC article. Review.

3

Detecting allosteric sites of HIV-1 reverse transcriptase by X-ray crystallographic fragment screening.

Bauman JD, Patel D, Dharia C, Fromer MW, Ahmed S, Frenkel Y, Vijayan RS, Eck JT, Ho WC, Das K, Shatkin AJ, Arnold E. Bauman JD, et al. Among authors: patel d. J Med Chem. 2013 Apr 11;56(7):2738-46. doi: 10.1021/jm301271j. Epub 2013 Feb 20. J Med Chem. 2013. PMID: 23342998 Free PMC article.

4

Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors.

Bauman JD, Patel D, Baker SF, Vijayan RS, Xiang A, Parhi AK, Martínez-Sobrido L, LaVoie EJ, Das K, Arnold E. Bauman JD, et al. Among authors: patel d. ACS Chem Biol. 2013 Nov 15;8(11):2501-8. doi: 10.1021/cb400400j. Epub 2013 Sep 13. ACS Chem Biol. 2013. PMID: 23978130 Free PMC article.

5

A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.

Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. Patel D, et al. J Biol Chem. 2016 Nov 4;291(45):23569-23577. doi: 10.1074/jbc.M116.753384. Epub 2016 Sep 19. J Biol Chem. 2016. PMID: 27645997 Free PMC article.

6

Phenyl substituted 3-hydroxypyridin-2(1H)-ones: inhibitors of influenza A endonuclease.

Parhi AK, Xiang A, Bauman JD, Patel D, Vijayan RS, Das K, Arnold E, Lavoie EJ. Parhi AK, et al. Among authors: patel d. Bioorg Med Chem. 2013 Nov 1;21(21):6435-46. doi: 10.1016/j.bmc.2013.08.053. Epub 2013 Sep 4. Bioorg Med Chem. 2013. PMID: 24055080

7

3-Hydroxyquinolin-2(1H)-ones As Inhibitors of Influenza A Endonuclease.

Sagong HY, Parhi A, Bauman JD, Patel D, Vijayan RS, Das K, Arnold E, LaVoie EJ. Sagong HY, et al. Among authors: patel d. ACS Med Chem Lett. 2013 May 7;4(6):547-50. doi: 10.1021/ml4001112. eCollection 2013 Jun 13. ACS Med Chem Lett. 2013. PMID: 24936242 Free PMC article.

8

Differential isotopic enrichment to facilitate characterization of asymmetric multimeric proteins using hydrogen/deuterium exchange mass spectrometry.

Goswami D, Tuske S, Pascal BD, Bauman JD, Patel D, Arnold E, Griffin PR. Goswami D, et al. Among authors: patel d. Anal Chem. 2015 Apr 7;87(7):4015-4022. doi: 10.1021/acs.analchem.5b00372. Epub 2015 Mar 25. Anal Chem. 2015. PMID: 25763479 Free PMC article.

9

Phenyl substituted 4-hydroxypyridazin-3(2H)-ones and 5-hydroxypyrimidin-4(3H)-ones: inhibitors of influenza A endonuclease.

Sagong HY, Bauman JD, Patel D, Das K, Arnold E, LaVoie EJ. Sagong HY, et al. Among authors: patel d. J Med Chem. 2014 Oct 9;57(19):8086-98. doi: 10.1021/jm500958x. Epub 2014 Sep 29. J Med Chem. 2014. PMID: 25225968 Free PMC article.

10

A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants.

Johnson BC, Pauly GT, Rai G, Patel D, Bauman JD, Baker HL, Das K, Schneider JP, Maloney DJ, Arnold E, Thomas CJ, Hughes SH. Johnson BC, et al. Among authors: patel d. Retrovirology. 2012 Dec 5;9:99. doi: 10.1186/1742-4690-9-99. Retrovirology. 2012. PMID: 23217210 Free PMC article.

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