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Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.
Xing L, Dai Z, Jabbari A, Cerise JE, Higgins CA, Gong W, de Jong A, Harel S, DeStefano GM, Rothman L, Singh P, Petukhova L, Mackay-Wiggan J, Christiano AM, Clynes R. Xing L, et al. Among authors: de jong a. Nat Med. 2014 Sep;20(9):1043-9. doi: 10.1038/nm.3645. Epub 2014 Aug 17. Nat Med. 2014. PMID: 25129481 Free PMC article.
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.
Betz RC, Petukhova L, Ripke S, Huang H, Menelaou A, Redler S, Becker T, Heilmann S, Yamany T, Duvic M, Hordinsky M, Norris D, Price VH, Mackay-Wiggan J, de Jong A, DeStefano GM, Moebus S, Böhm M, Blume-Peytavi U, Wolff H, Lutz G, Kruse R, Bian L, Amos CI, Lee A, Gregersen PK, Blaumeiser B, Altshuler D, Clynes R, de Bakker PIW, Nöthen MM, Daly MJ, Christiano AM. Betz RC, et al. Among authors: de jong a, de bakker piw. Nat Commun. 2015 Jan 22;6:5966. doi: 10.1038/ncomms6966. Nat Commun. 2015. PMID: 25608926 Free PMC article.
αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands.
Birkinshaw RW, Pellicci DG, Cheng TY, Keller AN, Sandoval-Romero M, Gras S, de Jong A, Uldrich AP, Moody DB, Godfrey DI, Rossjohn J. Birkinshaw RW, et al. Among authors: de jong a. Nat Immunol. 2015 Mar;16(3):258-66. doi: 10.1038/ni.3098. Epub 2015 Feb 2. Nat Immunol. 2015. PMID: 25642819 Free PMC article.
Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a.
Monnot GC, Wegrecki M, Cheng TY, Chen YL, Sallee BN, Chakravarthy R, Karantza IM, Tin SY, Khaleel AE, Monga I, Uwakwe LN, Tillman A, Cheng B, Youssef S, Ng SW, Shahine A, Garcia-Vilas JA, Uhlemann AC, Bordone LA, Han A, Rohde CH, Ogg G, Moody DB, Rossjohn J, de Jong A. Monnot GC, et al. Among authors: de jong a. Nat Immunol. 2023 Jan;24(1):110-122. doi: 10.1038/s41590-022-01375-z. Epub 2022 Dec 22. Nat Immunol. 2023. PMID: 36550321 Free PMC article.
1,243 results