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IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease.
Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. Ma HY, et al. Among authors: xu j. J Hepatol. 2020 May;72(5):946-959. doi: 10.1016/j.jhep.2019.12.016. Epub 2019 Dec 31. J Hepatol. 2020. PMID: 31899206 Free PMC article.
Notch, metabolism and macrophages.
Xu J, Chi F, Tsukamoto H. Xu J, et al. Oncotarget. 2015 Aug 21;6(24):19942-3. doi: 10.18632/oncotarget.4651. Oncotarget. 2015. PMID: 26343518 Free PMC article. No abstract available.
New Approaches for Studying Alcoholic Liver Disease.
Xu J, Liu X, Gao B, Karin M, Tsukamoto H, Brenner D, Kisseleva T. Xu J, et al. Curr Pathobiol Rep. 2014 Dec;2(4):171-183. doi: 10.1007/s40139-014-0053-z. Epub 2014 Sep 14. Curr Pathobiol Rep. 2014. PMID: 26594598 Free PMC article.
Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6.
Lai KKY, Kweon SM, Chi F, Hwang E, Kabe Y, Higashiyama R, Qin L, Yan R, Wu RP, Lai K, Fujii N, French S, Xu J, Wang JY, Murali R, Mishra L, Lee JS, Ntambi JM, Tsukamoto H. Lai KKY, et al. Among authors: xu j. Gastroenterology. 2017 May;152(6):1477-1491. doi: 10.1053/j.gastro.2017.01.021. Epub 2017 Jan 29. Gastroenterology. 2017. PMID: 28143772 Free PMC article.
Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice.
Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. Xu J, et al. JCI Insight. 2020 Feb 13;5(3):e131277. doi: 10.1172/jci.insight.131277. JCI Insight. 2020. PMID: 32051339 Free PMC article.
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