Expression of Y53A-actin in Dictyostelium disrupts the cytoskeleton and inhibits intracellular and intercellular chemotactic signaling.
Shu S, Liu X, Kriebel PW, Hong MS, Daniels MP, Parent CA, Korn ED.
Shu S, et al.
J Biol Chem. 2010 Sep 3;285(36):27713-25. doi: 10.1074/jbc.M110.116277. Epub 2010 Jul 7.
J Biol Chem. 2010.
PMID: 20610381
Free PMC article.
We showed previously that phosphorylation of Tyr(53), or its mutation to Ala, inhibits actin polymerization in vitro with formation of aggregates of short filaments, and that expression of Y53A-actin in Dictyostelium blocks differentiation and development at the mound stage (Liu, …
We showed previously that phosphorylation of Tyr(53), or its mutation to Ala, inhibits actin polymerization in vitro with formation of aggre …