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Page 1
GPER-1 and estrogen receptor-β ligands modulate aldosterone synthesis.
Caroccia B, Seccia TM, Campos AG, Gioco F, Kuppusamy M, Ceolotto G, Guerzoni E, Simonato F, Mareso S, Lenzini L, Fassina A, Rossi GP. Caroccia B, et al. Among authors: kuppusamy m. Endocrinology. 2014 Nov;155(11):4296-304. doi: 10.1210/en.2014-1416. Epub 2014 Aug 28. Endocrinology. 2014. PMID: 25167221
Lower expression of the TWIK-related acid-sensitive K+ channel 2 (TASK-2) gene is a hallmark of aldosterone-producing adenoma causing human primary aldosteronism.
Lenzini L, Caroccia B, Campos AG, Fassina A, Belloni AS, Seccia TM, Kuppusamy M, Ferraro S, Skander G, Bader M, Rainey WE, Rossi GP. Lenzini L, et al. Among authors: kuppusamy m. J Clin Endocrinol Metab. 2014 Apr;99(4):E674-82. doi: 10.1210/jc.2013-2900. Epub 2013 Nov 27. J Clin Endocrinol Metab. 2014. PMID: 24285684
A novel KCNJ5-insT149 somatic mutation close to, but outside, the selectivity filter causes resistant hypertension by loss of selectivity for potassium.
Kuppusamy M, Caroccia B, Stindl J, Bandulik S, Lenzini L, Gioco F, Fishman V, Zanotti G, Gomez-Sanchez C, Bader M, Warth R, Rossi GP. Kuppusamy M, et al. J Clin Endocrinol Metab. 2014 Sep;99(9):E1765-73. doi: 10.1210/jc.2014-1927. Epub 2014 Jul 24. J Clin Endocrinol Metab. 2014. PMID: 25057880 Free PMC article.
KCNJ5 gene somatic mutations affect cardiac remodelling but do not preclude cure of high blood pressure and regression of left ventricular hypertrophy in primary aldosteronism.
Rossi GP, Cesari M, Letizia C, Seccia TM, Cicala MV, Zinnamosca L, Kuppusamy M, Mareso S, Sciomer S, Iacobone M, Mantero F, Pessina AC. Rossi GP, et al. Among authors: kuppusamy m. J Hypertens. 2014 Jul;32(7):1514-21; discussion 1522. doi: 10.1097/HJH.0000000000000186. J Hypertens. 2014. PMID: 24759126
miR-30c-5p regulates macrophage-mediated inflammation and pro-atherosclerosis pathways.
Ceolotto G, Giannella A, Albiero M, Kuppusamy M, Radu C, Simioni P, Garlaschelli K, Baragetti A, Catapano AL, Iori E, Fadini GP, Avogaro A, Vigili de Kreutzenberg S. Ceolotto G, et al. Among authors: kuppusamy m. Cardiovasc Res. 2017 Nov 1;113(13):1627-1638. doi: 10.1093/cvr/cvx157. Cardiovasc Res. 2017. PMID: 29016810
Somatic mutations of the ATP1A1 gene and aldosterone-producing adenomas.
Gomez-Sanchez CE, Kuppusamy M, Gomez-Sanchez EP. Gomez-Sanchez CE, et al. Among authors: kuppusamy m. Mol Cell Endocrinol. 2015 Jun 15;408:213-9. doi: 10.1016/j.mce.2014.12.004. Epub 2014 Dec 10. Mol Cell Endocrinol. 2015. PMID: 25496839 Free PMC article. Review.
165 results