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HDX-MS guided drug discovery: small molecules and biopharmaceuticals.
Marciano DP, Dharmarajan V, Griffin PR. Marciano DP, et al. Among authors: dharmarajan v. Curr Opin Struct Biol. 2014 Oct;28:105-11. doi: 10.1016/j.sbi.2014.08.007. Epub 2014 Aug 30. Curr Opin Struct Biol. 2014. PMID: 25179005 Free PMC article. Review.
Conformational states of the full-length glucagon receptor.
Yang L, Yang D, de Graaf C, Moeller A, West GM, Dharmarajan V, Wang C, Siu FY, Song G, Reedtz-Runge S, Pascal BD, Wu B, Potter CS, Zhou H, Griffin PR, Carragher B, Yang H, Wang MW, Stevens RC, Jiang H. Yang L, et al. Among authors: dharmarajan v. Nat Commun. 2015 Jul 31;6:7859. doi: 10.1038/ncomms8859. Nat Commun. 2015. PMID: 26227798 Free PMC article.
Biophysical Interactions of Direct AMPK Activators.
Kurumbail RG, West GM, Dharmarajan V, Borzilleri KA, Withka JM, Ward J, Reyes AR, Rajamohan F, Griffin PR, Calabrese MF. Kurumbail RG, et al. Among authors: dharmarajan v. Methods Mol Biol. 2018;1732:29-55. doi: 10.1007/978-1-4939-7598-3_3. Methods Mol Biol. 2018. PMID: 29480467
Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists.
Lin H, Doebelin C, Patouret R, Garcia-Ordonez RD, Chang MR, Dharmarajan V, Bayona CR, Cameron MD, Griffin PR, Kamenecka TM. Lin H, et al. Among authors: dharmarajan v. Bioorg Med Chem Lett. 2018 May 1;28(8):1313-1319. doi: 10.1016/j.bmcl.2018.03.019. Epub 2018 Mar 8. Bioorg Med Chem Lett. 2018. PMID: 29548571 Free PMC article.
Identification of potent RORβ modulators: Scaffold variation.
Doebelin C, Patouret R, Garcia-Ordonez RD, Chang MR, Dharmarajan V, Novick S, Ciesla A, Campbell S, Solt LA, Griffin PR, Kamenecka TM. Doebelin C, et al. Among authors: dharmarajan v. Bioorg Med Chem Lett. 2018 Oct 15;28(19):3210-3215. doi: 10.1016/j.bmcl.2018.08.017. Epub 2018 Aug 16. Bioorg Med Chem Lett. 2018. PMID: 30143422 Free PMC article.
Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1.
de Vera IMS, Munoz-Tello P, Zheng J, Dharmarajan V, Marciano DP, Matta-Camacho E, Giri PK, Shang J, Hughes TS, Rance M, Griffin PR, Kojetin DJ. de Vera IMS, et al. Among authors: dharmarajan v. Structure. 2019 Jan 2;27(1):66-77.e5. doi: 10.1016/j.str.2018.10.002. Epub 2018 Nov 8. Structure. 2019. PMID: 30416039 Free PMC article.
57 results