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Neoadjuvant anti-tumor vaccination prior to surgery enhances survival.
Fisher SA, Cleaver A, Lakhiani DD, Khong A, Connor T, Wylie B, Lesterhuis WJ, Robinson BW, Lake RA. Fisher SA, et al. Among authors: wylie b. J Transl Med. 2014 Sep 4;12:245. doi: 10.1186/s12967-014-0245-7. J Transl Med. 2014. PMID: 25186961 Free PMC article.
A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrence.
Rwandamuriye FX, Evans CW, Wylie B, Norret M, Vitali B, Ho D, Nguyen D, Roper EA, Wang T, Hepburn MS, Sanderson RW, Pfirrmann M, Fear VS, Forbes CA, Wyatt K, Ryan AL, Johns TG, Phillips MB, Hodder R, Leslie C, Kennedy BF, Zemek RM, Iyer KS, Lesterhuis WJ. Rwandamuriye FX, et al. Among authors: wylie b. Cell Rep Med. 2023 Jul 18;4(7):101113. doi: 10.1016/j.xcrm.2023.101113. Cell Rep Med. 2023. PMID: 37467718 Free PMC article.
Local therapy with combination TLR agonists stimulates systemic anti-tumor immunity and sensitizes tumors to immune checkpoint blockade.
Rwandamuriye FX, Wang T, Zhang H, Elaskalani O, Kuster J, Ye X, Vitali B, Schreurs J, Orozco Morales ML, Norret M, Evans CW, Zemek RM, Iyer KS, Lesterhuis WJ, Wylie B. Rwandamuriye FX, et al. Among authors: wylie b. Oncoimmunology. 2024 Aug 22;13(1):2395067. doi: 10.1080/2162402X.2024.2395067. eCollection 2024. Oncoimmunology. 2024. PMID: 39188754 Free PMC article.
Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockade.
Principe N, Phung AL, Stevens KLP, Elaskalani O, Wylie B, Tilsed CM, Sheikh F, Orozco Morales ML, Kidman J, Marcq E, Fisher SA, Nowak AK, McDonnell AM, Lesterhuis WJ, Chee J. Principe N, et al. Among authors: wylie b. J Immunother Cancer. 2024 Sep 28;12(9):e008568. doi: 10.1136/jitc-2023-008568. J Immunother Cancer. 2024. PMID: 39343508 Free PMC article.
318 results