Kraft MB - Search Results

1

Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone core.

Kraft MB, Poudel YB, Kedei N, Lewin NE, Peach ML, Blumberg PM, Keck GE. Kraft MB, et al. J Am Chem Soc. 2014 Sep 24;136(38):13202-8. doi: 10.1021/ja5078188. Epub 2014 Sep 10. J Am Chem Soc. 2014. PMID: 25207434 Free PMC article.

2

Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function.

Keck GE, Kraft MB, Truong AP, Li W, Sanchez CC, Kedei N, Lewin NE, Blumberg PM. Keck GE, et al. Among authors: kraft mb. J Am Chem Soc. 2008 May 28;130(21):6660-1. doi: 10.1021/ja8022169. Epub 2008 May 2. J Am Chem Soc. 2008. PMID: 18452293 Free PMC article.

3

Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters.

Keck GE, Poudel YB, Welch DS, Kraft MB, Truong AP, Stephens JC, Kedei N, Lewin NE, Blumberg PM. Keck GE, et al. Among authors: kraft mb. Org Lett. 2009 Feb 5;11(3):593-6. doi: 10.1021/ol8027253. Org Lett. 2009. PMID: 19113896 Free PMC article.

4

The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses.

Keck GE, Li W, Kraft MB, Kedei N, Lewin NE, Blumberg PM. Keck GE, et al. Among authors: kraft mb. Org Lett. 2009 Jun 4;11(11):2277-80. doi: 10.1021/ol900585t. Org Lett. 2009. PMID: 19419164 Free PMC article.

5

Neristatin 1 provides critical insight into bryostatin 1 structure-function relationships.

Kedei N, Kraft MB, Keck GE, Herald CL, Melody N, Pettit GR, Blumberg PM. Kedei N, et al. Among authors: kraft mb. J Nat Prod. 2015 Apr 24;78(4):896-900. doi: 10.1021/acs.jnatprod.5b00094. Epub 2015 Mar 26. J Nat Prod. 2015. PMID: 25808573 Free PMC article.

6

Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action.

Kedei N, Telek A, Michalowski AM, Kraft MB, Li W, Poudel YB, Rudra A, Petersen ME, Keck GE, Blumberg PM. Kedei N, et al. Among authors: kraft mb. Biochem Pharmacol. 2013 Feb 1;85(3):313-24. doi: 10.1016/j.bcp.2012.10.028. Epub 2012 Nov 9. Biochem Pharmacol. 2013. PMID: 23146662 Free PMC article.

7

Total synthesis of epothilones B and D: stannane equivalents for beta-keto ester dianions.

Keck GE, Giles RL, Cee VJ, Wager CA, Yu T, Kraft MB. Keck GE, et al. Among authors: kraft mb. J Org Chem. 2008 Dec 19;73(24):9675-91. doi: 10.1021/jo802215v. J Org Chem. 2008. PMID: 18991385 Free PMC article.

8

Some phorbol esters might partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cells.

Kedei N, Lubart E, Lewin NE, Telek A, Lim L, Mannan P, Garfield SH, Kraft MB, Keck GE, Kolusheva S, Jelinek R, Blumberg PM. Kedei N, et al. Among authors: kraft mb. Chembiochem. 2011 May 16;12(8):1242-51. doi: 10.1002/cbic.201100064. Epub 2011 May 3. Chembiochem. 2011. PMID: 21542090 Free PMC article.

9

The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line.

Kedei N, Telek A, Czap A, Lubart ES, Czifra G, Yang D, Chen J, Morrison T, Goldsmith PK, Lim L, Mannan P, Garfield SH, Kraft MB, Li W, Keck GE, Blumberg PM. Kedei N, et al. Among authors: kraft mb. Biochem Pharmacol. 2011 Jun 1;81(11):1296-308. doi: 10.1016/j.bcp.2011.03.018. Epub 2011 Mar 30. Biochem Pharmacol. 2011. PMID: 21458422 Free PMC article.

10

Bacterial Cell Wall Modification with a Glycolipid Substrate.

Calabretta PJ, Hodges HL, Kraft MB, Marando VM, Kiessling LL. Calabretta PJ, et al. Among authors: kraft mb. J Am Chem Soc. 2019 Jun 12;141(23):9262-9272. doi: 10.1021/jacs.9b02290. Epub 2019 Jun 4. J Am Chem Soc. 2019. PMID: 31081628 Free PMC article.

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