Hartmann RW - Search Results

1

Binding mode characterization of novel RNA polymerase inhibitors using a combined biochemical and NMR approach.

Fruth M, Plaza A, Hinsberger S, Sahner JH, Haupenthal J, Bischoff M, Jansen R, Müller R, Hartmann RW. Fruth M, et al. Among authors: hartmann rw. ACS Chem Biol. 2014 Nov 21;9(11):2656-63. doi: 10.1021/cb5005433. Epub 2014 Sep 26. ACS Chem Biol. 2014. PMID: 25207839

2

Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.

Hu Q, Jagusch C, Hille UE, Haupenthal J, Hartmann RW. Hu Q, et al. Among authors: hartmann rw. J Med Chem. 2010 Aug 12;53(15):5749-58. doi: 10.1021/jm100317b. J Med Chem. 2010. PMID: 20684610

3

Bicyclic substituted hydroxyphenylmethanones as novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases.

Oster A, Hinsberger S, Werth R, Marchais-Oberwinkler S, Frotscher M, Hartmann RW. Oster A, et al. Among authors: hartmann rw. J Med Chem. 2010 Nov 25;53(22):8176-86. doi: 10.1021/jm101073q. Epub 2010 Oct 26. J Med Chem. 2010. PMID: 20977238

4

Synthesis of some novel androstanes as potential aromatase inhibitors.

Yadav MR, Sabale PM, Giridhar R, Zimmer C, Haupenthal J, Hartmann RW. Yadav MR, et al. Among authors: hartmann rw. Steroids. 2011 Apr;76(5):464-70. doi: 10.1016/j.steroids.2010.12.013. Epub 2011 Jan 6. Steroids. 2011. PMID: 21215765

5

Biosynthesis of 2-Alkyl-4(1H)-quinolones in Pseudomonas aeruginosa: potential for therapeutic interference with pathogenicity.

Pistorius D, Ullrich A, Lucas S, Hartmann RW, Kazmaier U, Müller R. Pistorius D, et al. Among authors: hartmann rw. Chembiochem. 2011 Apr 11;12(6):850-3. doi: 10.1002/cbic.201100014. Epub 2011 Mar 18. Chembiochem. 2011. PMID: 21425231 No abstract available.

6

Computational investigation of the binding mode of bis(hydroxylphenyl)arenes in 17β-HSD1: molecular dynamics simulations, MM-PBSA free energy calculations, and molecular electrostatic potential maps.

Negri M, Recanatini M, Hartmann RW. Negri M, et al. Among authors: hartmann rw. J Comput Aided Mol Des. 2011 Sep;25(9):795-811. doi: 10.1007/s10822-011-9464-7. Epub 2011 Aug 6. J Comput Aided Mol Des. 2011. PMID: 21822722

7

Discovery of a new class of bicyclic substituted hydroxyphenylmethanones as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors for the treatment of osteoporosis.

Wetzel M, Gargano EM, Hinsberger S, Marchais-Oberwinkler S, Hartmann RW. Wetzel M, et al. Among authors: hartmann rw. Eur J Med Chem. 2012 Jan;47(1):1-17. doi: 10.1016/j.ejmech.2011.09.004. Epub 2011 Sep 8. Eur J Med Chem. 2012. PMID: 21945251

8

Influence of DNA template choice on transcription and inhibition of Escherichia coli RNA polymerase.

Haupenthal J, Hüsecken K, Negri M, Maurer CK, Hartmann RW. Haupenthal J, et al. Among authors: hartmann rw. Antimicrob Agents Chemother. 2012 Aug;56(8):4536-9. doi: 10.1128/AAC.00198-12. Epub 2012 Jun 4. Antimicrob Agents Chemother. 2012. PMID: 22664971 Free PMC article.

9

Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit discovery and optimization.

Klein T, Henn C, de Jong JC, Zimmer C, Kirsch B, Maurer CK, Pistorius D, Müller R, Steinbach A, Hartmann RW. Klein T, et al. Among authors: hartmann rw. ACS Chem Biol. 2012 Sep 21;7(9):1496-501. doi: 10.1021/cb300208g. Epub 2012 Jul 5. ACS Chem Biol. 2012. PMID: 22765028

10

Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5α-reductase inhibitors: a legitimate approach.

Aggarwal S, Thareja S, Bhardwaj TR, Haupenthal J, Hartmann RW, Kumar M. Aggarwal S, et al. Among authors: hartmann rw. Eur J Med Chem. 2012 Aug;54:728-39. doi: 10.1016/j.ejmech.2012.06.026. Epub 2012 Jun 21. Eur J Med Chem. 2012. PMID: 22776417

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