Dexheimer TS - Search Results

1

Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.

Dexheimer TS, Rosenthal AS, Luci DK, Liang Q, Villamil MA, Chen J, Sun H, Kerns EH, Simeonov A, Jadhav A, Zhuang Z, Maloney DJ. Dexheimer TS, et al. J Med Chem. 2014 Oct 9;57(19):8099-110. doi: 10.1021/jm5010495. Epub 2014 Sep 17. J Med Chem. 2014. PMID: 25229643 Free PMC article.

2

Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.

Dexheimer TS, Antony S, Marchand C, Pommier Y. Dexheimer TS, et al. Anticancer Agents Med Chem. 2008 May;8(4):381-9. doi: 10.2174/187152008784220357. Anticancer Agents Med Chem. 2008. PMID: 18473723 Free PMC article. Review.

3

Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.

Cinelli MA, Morrell A, Dexheimer TS, Scher ES, Pommier Y, Cushman M. Cinelli MA, et al. Among authors: dexheimer ts. J Med Chem. 2008 Aug 14;51(15):4609-19. doi: 10.1021/jm800259e. Epub 2008 Jul 17. J Med Chem. 2008. PMID: 18630891 Free PMC article.

4

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay.

Marchand C, Lea WA, Jadhav A, Dexheimer TS, Austin CP, Inglese J, Pommier Y, Simeonov A. Marchand C, et al. Among authors: dexheimer ts. Mol Cancer Ther. 2009 Jan;8(1):240-8. doi: 10.1158/1535-7163.MCT-08-0878. Mol Cancer Ther. 2009. PMID: 19139134 Free PMC article.

5

Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.

Cinelli MA, Cordero B, Dexheimer TS, Pommier Y, Cushman M. Cinelli MA, et al. Among authors: dexheimer ts. Bioorg Med Chem. 2009 Oct 15;17(20):7145-55. doi: 10.1016/j.bmc.2009.08.066. Epub 2009 Sep 6. Bioorg Med Chem. 2009. PMID: 19783447 Free PMC article.

6

4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.

Dexheimer TS, Gediya LK, Stephen AG, Weidlich I, Antony S, Marchand C, Interthal H, Nicklaus M, Fisher RJ, Njar VC, Pommier Y. Dexheimer TS, et al. J Med Chem. 2009 Nov 26;52(22):7122-31. doi: 10.1021/jm901061s. J Med Chem. 2009. PMID: 19883083 Free PMC article.

7

Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors.

Song Y, Shao Z, Dexheimer TS, Scher ES, Pommier Y, Cushman M. Song Y, et al. Among authors: dexheimer ts. J Med Chem. 2010 Mar 11;53(5):1979-89. doi: 10.1021/jm901649x. J Med Chem. 2010. PMID: 20155916 Free PMC article.

8

Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay.

Prast-Nielsen S, Dexheimer TS, Schultz L, Stafford WC, Cheng Q, Xu J, Jadhav A, Arnér ES, Simeonov A. Prast-Nielsen S, et al. Among authors: dexheimer ts. Free Radic Biol Med. 2011 May 1;50(9):1114-23. doi: 10.1016/j.freeradbiomed.2011.01.020. Epub 2011 Jan 22. Free Radic Biol Med. 2011. PMID: 21262347 Free PMC article.

9

Exploratory analysis of kinetic solubility measurements of a small molecule library.

Guha R, Dexheimer TS, Kestranek AN, Jadhav A, Chervenak AM, Ford MG, Simeonov A, Roth GP, Thomas CJ. Guha R, et al. Among authors: dexheimer ts. Bioorg Med Chem. 2011 Jul 1;19(13):4127-34. doi: 10.1016/j.bmc.2011.05.005. Epub 2011 May 13. Bioorg Med Chem. 2011. PMID: 21640593 Free PMC article.

10

7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents.

Kiselev E, DeGuire S, Morrell A, Agama K, Dexheimer TS, Pommier Y, Cushman M. Kiselev E, et al. Among authors: dexheimer ts. J Med Chem. 2011 Sep 8;54(17):6106-16. doi: 10.1021/jm200719v. Epub 2011 Aug 8. J Med Chem. 2011. PMID: 21823606 Free PMC article.

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