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Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor.
Free RB, Chun LS, Moritz AE, Miller BN, Doyle TB, Conroy JL, Padron A, Meade JA, Xiao J, Hu X, Dulcey AE, Han Y, Duan L, Titus S, Bryant-Genevier M, Barnaeva E, Ferrer M, Javitch JA, Beuming T, Shi L, Southall NT, Marugan JJ, Sibley DR. Free RB, et al. Among authors: conroy jl. Mol Pharmacol. 2014 Jul;86(1):96-105. doi: 10.1124/mol.113.090563. Epub 2014 Apr 22. Mol Pharmacol. 2014. PMID: 24755247 Free PMC article.
Identification of Positive Allosteric Modulators of the D1 Dopamine Receptor That Act at Diverse Binding Sites.
Luderman KD, Conroy JL, Free RB, Southall N, Ferrer M, Sanchez-Soto M, Moritz AE, Willette BKA, Fyfe TJ, Jain P, Titus S, Hazelwood LA, Aubé J, Lane JR, Frankowski KJ, Sibley DR. Luderman KD, et al. Among authors: conroy jl. Mol Pharmacol. 2018 Oct;94(4):1197-1209. doi: 10.1124/mol.118.113175. Epub 2018 Aug 1. Mol Pharmacol. 2018. PMID: 30068735 Free PMC article.
Development of pyrimidone D1 dopamine receptor positive allosteric modulators.
Luderman KD, Jain P, Benjamin Free R, Conroy JL, Aubé J, Sibley DR, Frankowski KJ. Luderman KD, et al. Among authors: conroy jl. Bioorg Med Chem Lett. 2021 Jan 1;31:127696. doi: 10.1016/j.bmcl.2020.127696. Epub 2020 Nov 19. Bioorg Med Chem Lett. 2021. PMID: 33221389 Free PMC article.
PNA-Based Multivalent Scaffolds Activate the Dopamine D2 Receptor.
Dix AV, Conroy JL, George Rosenker KM, Sibley DR, Appella DH. Dix AV, et al. Among authors: conroy jl. ACS Med Chem Lett. 2015 Mar 13;6(4):425-9. doi: 10.1021/ml500478m. eCollection 2015 Apr 9. ACS Med Chem Lett. 2015. PMID: 25893044 Free PMC article.
Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling.
Conroy JL, Fang C, Gu J, Zeitlin SO, Yang W, Yang J, VanAlstine MA, Nalwalk JW, Albrecht PJ, Mazurkiewicz JE, Snyder-Keller A, Shan Z, Zhang SZ, Wentland MP, Behr M, Knapp BI, Bidlack JM, Zuiderveld OP, Leurs R, Ding X, Hough LB. Conroy JL, et al. Nat Neurosci. 2010 Mar;13(3):284-6. doi: 10.1038/nn.2497. Epub 2010 Feb 7. Nat Neurosci. 2010. PMID: 20139973 Free PMC article.
37 results