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Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice.
Missios P, Zhou Y, Guachalla LM, von Figura G, Wegner A, Chakkarappan SR, Binz T, Gompf A, Hartleben G, Burkhalter MD, Wulff V, Günes C, Sattler RW, Song Z, Illig T, Klaus S, Böhm BO, Wenz T, Hiller K, Rudolph KL. Missios P, et al. Among authors: wenz t. Nat Commun. 2014 Sep 18;5:4924. doi: 10.1038/ncomms5924. Nat Commun. 2014. PMID: 25233189 Free PMC article.
MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention.
Tischner C, Hofer A, Wulff V, Stepek J, Dumitru I, Becker L, Haack T, Kremer L, Datta AN, Sperl W, Floss T, Wurst W, Chrzanowska-Lightowlers Z, De Angelis MH, Klopstock T, Prokisch H, Wenz T. Tischner C, et al. Among authors: wenz t. Hum Mol Genet. 2015 Apr 15;24(8):2247-66. doi: 10.1093/hmg/ddu743. Epub 2014 Dec 30. Hum Mol Genet. 2015. PMID: 25552653 Free PMC article.
MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy.
Becker L, Kling E, Schiller E, Zeh R, Schrewe A, Hölter SM, Mossbrugger I, Calzada-Wack J, Strecker V, Wittig I, Dumitru I, Wenz T, Bender A, Aichler M, Janik D, Neff F, Walch A, Quintanilla-Fend L, Floss T, Bekeredjian R, Gailus-Durner V, Fuchs H, Wurst W, Meitinger T, Prokisch H, de Angelis MH, Klopstock T. Becker L, et al. Among authors: wenz t. PLoS One. 2014 Dec 15;9(12):e114918. doi: 10.1371/journal.pone.0114918. eCollection 2014. PLoS One. 2014. PMID: 25506927 Free PMC article.
37 results