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Aziridine-2,3-dicarboxylate-based cysteine cathepsin inhibitors induce cell death in Leishmania major associated with accumulation of debris in autophagy-related lysosome-like vacuoles.
Schurigt U, Schad C, Glowa C, Baum U, Thomale K, Schnitzer JK, Schultheis M, Schaschke N, Schirmeister T, Moll H. Schurigt U, et al. Among authors: schirmeister t. Antimicrob Agents Chemother. 2010 Dec;54(12):5028-41. doi: 10.1128/AAC.00327-10. Epub 2010 Sep 20. Antimicrob Agents Chemother. 2010. PMID: 20855728 Free PMC article.
Development of a New Antileishmanial Aziridine-2,3-Dicarboxylate-Based Inhibitor with High Selectivity for Parasite Cysteine Proteases.
Schad C, Baum U, Frank B, Dietzel U, Mattern F, Gomes C, Ponte-Sucre A, Moll H, Schurigt U, Schirmeister T. Schad C, et al. Among authors: schirmeister t. Antimicrob Agents Chemother. 2015 Nov 23;60(2):797-805. doi: 10.1128/AAC.00426-15. Print 2016 Feb. Antimicrob Agents Chemother. 2015. PMID: 26596939 Free PMC article.
Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.
Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC. Caffrey CR, et al. Among authors: schirmeister t. Antimicrob Agents Chemother. 2007 Jun;51(6):2164-72. doi: 10.1128/AAC.01418-06. Epub 2007 Mar 19. Antimicrob Agents Chemother. 2007. PMID: 17371810 Free PMC article.
208 results