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Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen.
Pham TA, Clare S, Goulding D, Arasteh JM, Stares MD, Browne HP, Keane JA, Page AJ, Kumasaka N, Kane L, Mottram L, Harcourt K, Hale C, Arends MJ, Gaffney DJ; Sanger Mouse Genetics Project; Dougan G, Lawley TD. Pham TA, et al. Among authors: lawley td. Cell Host Microbe. 2014 Oct 8;16(4):504-16. doi: 10.1016/j.chom.2014.08.017. Epub 2014 Sep 25. Cell Host Microbe. 2014. PMID: 25263220 Free PMC article.
Antibiotic treatment of clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts.
Lawley TD, Clare S, Walker AW, Goulding D, Stabler RA, Croucher N, Mastroeni P, Scott P, Raisen C, Mottram L, Fairweather NF, Wren BW, Parkhill J, Dougan G. Lawley TD, et al. Infect Immun. 2009 Sep;77(9):3661-9. doi: 10.1128/IAI.00558-09. Epub 2009 Jun 29. Infect Immun. 2009. PMID: 19564382 Free PMC article.
The Clostridium difficile spo0A gene is a persistence and transmission factor.
Deakin LJ, Clare S, Fagan RP, Dawson LF, Pickard DJ, West MR, Wren BW, Fairweather NF, Dougan G, Lawley TD. Deakin LJ, et al. Among authors: lawley td. Infect Immun. 2012 Aug;80(8):2704-11. doi: 10.1128/IAI.00147-12. Epub 2012 May 21. Infect Immun. 2012. PMID: 22615253 Free PMC article.
Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice.
Lawley TD, Clare S, Walker AW, Stares MD, Connor TR, Raisen C, Goulding D, Rad R, Schreiber F, Brandt C, Deakin LJ, Pickard DJ, Duncan SH, Flint HJ, Clark TG, Parkhill J, Dougan G. Lawley TD, et al. PLoS Pathog. 2012;8(10):e1002995. doi: 10.1371/journal.ppat.1002995. Epub 2012 Oct 25. PLoS Pathog. 2012. PMID: 23133377 Free PMC article.
Intestinal colonization resistance.
Lawley TD, Walker AW. Lawley TD, et al. Immunology. 2013 Jan;138(1):1-11. doi: 10.1111/j.1365-2567.2012.03616.x. Immunology. 2013. PMID: 23240815 Free PMC article. Review.
134 results