O'Keefe BR - Search Results

1

The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus.

Garrison AR, Giomarelli BG, Lear-Rooney CM, Saucedo CJ, Yellayi S, Krumpe LR, Rose M, Paragas J, Bray M, Olinger GG Jr, McMahon JB, Huggins J, O'Keefe BR. Garrison AR, et al. Antiviral Res. 2014 Dec;112:1-7. doi: 10.1016/j.antiviral.2014.09.012. Epub 2014 Oct 5. Antiviral Res. 2014. PMID: 25265598 Free PMC article.

2

Isolation and characterization of niphatevirin, a human-immunodeficiency-virus-inhibitory glycoprotein from the marine sponge Niphates erecta.

O'Keefe BR, Beutler JA, Cardellina JH 2nd, Gulakowski RJ, Krepps BL, McMahon JB, Sowder RC 2nd, Henderson LE, Pannell LK, Pomponi SA, Boyd MR. O'Keefe BR, et al. Eur J Biochem. 1997 Apr 1;245(1):47-53. doi: 10.1111/j.1432-1033.1997.t01-1-00047.x. Eur J Biochem. 1997. PMID: 9128723 Free article.

3

Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development.

Boyd MR, Gustafson KR, McMahon JB, Shoemaker RH, O'Keefe BR, Mori T, Gulakowski RJ, Wu L, Rivera MI, Laurencot CM, Currens MJ, Cardellina JH 2nd, Buckheit RW Jr, Nara PL, Pannell LK, Sowder RC 2nd, Henderson LE. Boyd MR, et al. Antimicrob Agents Chemother. 1997 Jul;41(7):1521-30. doi: 10.1128/AAC.41.7.1521. Antimicrob Agents Chemother. 1997. PMID: 9210678 Free PMC article.

4

Isolation and characterization of adociavirin, a novel HIV-inhibitory protein from the sponge Adocia sp.

O'Keefe BR, Erim T, Beutler JA, Cardellina JH 2nd, Gulakowski RJ, Krepps BL, McMahon JB, Sowder RC 2nd, Johnson DG, Buckheit RW Jr, Halliday S, Boyd MR. O'Keefe BR, et al. FEBS Lett. 1998 Jul 10;431(1):85-90. doi: 10.1016/s0014-5793(98)00736-4. FEBS Lett. 1998. PMID: 9684871 Free article.

5

The HIV-inactivating protein, cyanovirin-N, does not block gp120-mediated virus-to-cell binding.

Mariner JM, McMahon JB, O'Keefe BR, Nagashima K, Boyd MR. Mariner JM, et al. Biochem Biophys Res Commun. 1998 Jul 30;248(3):841-5. doi: 10.1006/bbrc.1998.9060. Biochem Biophys Res Commun. 1998. PMID: 9704015

6

Development of a cyanovirin-N-HIV-1 gp120 binding assay for high throughput screening of natural product extracts by time-resolved fluorescence.

McMahon JB, Beutler JA, O'Keefe BR, Goodrum CB, Myers MA, Boyd MR. McMahon JB, et al. J Biomol Screen. 2000 Jun;5(3):169-76. doi: 10.1177/108705710000500309. J Biomol Screen. 2000. PMID: 10894760

7

Cyanovirin-N defines a new class of antiviral agent targeting N-linked, high-mannose glycans in an oligosaccharide-specific manner.

Bolmstedt AJ, O'Keefe BR, Shenoy SR, McMahon JB, Boyd MR. Bolmstedt AJ, et al. Mol Pharmacol. 2001 May;59(5):949-54. doi: 10.1124/mol.59.5.949. Mol Pharmacol. 2001. PMID: 11306674

8

High throughput screening for cyanovirin-N mimetics binding to HIV-1 gp41.

Beutler JA, McMahon JB, Johnson TR, O'Keefe BR, Buzzell RA, Robbins D, Gardella R, Wilson J, Boyd MR. Beutler JA, et al. J Biomol Screen. 2002 Apr;7(2):105-10. doi: 10.1177/108705710200700202. J Biomol Screen. 2002. PMID: 12006108

9

Cyanovirin-N binds to the viral surface glycoprotein, GP1,2 and inhibits infectivity of Ebola virus.

Barrientos LG, O'Keefe BR, Bray M, Sanchez A, Gronenborn AM, Boyd MR. Barrientos LG, et al. Antiviral Res. 2003 Mar;58(1):47-56. doi: 10.1016/s0166-3542(02)00183-3. Antiviral Res. 2003. PMID: 12719006

10

Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin.

O'Keefe BR, Smee DF, Turpin JA, Saucedo CJ, Gustafson KR, Mori T, Blakeslee D, Buckheit R, Boyd MR. O'Keefe BR, et al. Antimicrob Agents Chemother. 2003 Aug;47(8):2518-25. doi: 10.1128/AAC.47.8.2518-2525.2003. Antimicrob Agents Chemother. 2003. PMID: 12878514 Free PMC article.

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