Simeonov A - Search Results

1

Covalent small molecule inhibitors of Ca(2+)-bound S100B.

Cavalier MC, Pierce AD, Wilder PT, Alasady MJ, Hartman KG, Neau DB, Foley TL, Jadhav A, Maloney DJ, Simeonov A, Toth EA, Weber DJ. Cavalier MC, et al. Among authors: simeonov a. Biochemistry. 2014 Oct 28;53(42):6628-40. doi: 10.1021/bi5005552. Epub 2014 Oct 14. Biochemistry. 2014. PMID: 25268459 Free PMC article.

2

Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction.

Simeonov A, Yasgar A, Jadhav A, Lokesh GL, Klumpp C, Michael S, Austin CP, Natarajan A, Inglese J. Simeonov A, et al. Anal Biochem. 2008 Apr 1;375(1):60-70. doi: 10.1016/j.ab.2007.11.039. Epub 2007 Dec 5. Anal Biochem. 2008. PMID: 18158907 Free PMC article.

3

Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade.

Simeonov A, Jadhav A, Sayed AA, Wang Y, Nelson ME, Thomas CJ, Inglese J, Williams DL, Austin CP. Simeonov A, et al. PLoS Negl Trop Dis. 2008 Jan 2;2(1):e127. doi: 10.1371/journal.pntd.0000127. PLoS Negl Trop Dis. 2008. PMID: 18235848 Free PMC article.

4

Characterization of chemical libraries for luciferase inhibitory activity.

Auld DS, Southall NT, Jadhav A, Johnson RL, Diller DJ, Simeonov A, Austin CP, Inglese J. Auld DS, et al. Among authors: simeonov a. J Med Chem. 2008 Apr 24;51(8):2372-86. doi: 10.1021/jm701302v. Epub 2008 Mar 26. J Med Chem. 2008. PMID: 18363348

5

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay.

Marchand C, Lea WA, Jadhav A, Dexheimer TS, Austin CP, Inglese J, Pommier Y, Simeonov A. Marchand C, et al. Among authors: simeonov a. Mol Cancer Ther. 2009 Jan;8(1):240-8. doi: 10.1158/1535-7163.MCT-08-0878. Mol Cancer Ther. 2009. PMID: 19139134 Free PMC article.

6

Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.

Rai G, Sayed AA, Lea WA, Luecke HF, Chakrapani H, Prast-Nielsen S, Jadhav A, Leister W, Shen M, Inglese J, Austin CP, Keefer L, Arnér ES, Simeonov A, Maloney DJ, Williams DL, Thomas CJ. Rai G, et al. Among authors: simeonov a. J Med Chem. 2009 Oct 22;52(20):6474-83. doi: 10.1021/jm901021k. J Med Chem. 2009. PMID: 19761212 Free PMC article.

7

A high-throughput approach for identification of novel general anesthetics.

Lea WA, Xi J, Jadhav A, Lu L, Austin CP, Simeonov A, Eckenhoff RG. Lea WA, et al. Among authors: simeonov a. PLoS One. 2009 Sep 24;4(9):e7150. doi: 10.1371/journal.pone.0007150. PLoS One. 2009. PMID: 19777064 Free PMC article.

8

Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.

Jadhav A, Ferreira RS, Klumpp C, Mott BT, Austin CP, Inglese J, Thomas CJ, Maloney DJ, Shoichet BK, Simeonov A. Jadhav A, et al. Among authors: simeonov a. J Med Chem. 2010 Jan 14;53(1):37-51. doi: 10.1021/jm901070c. J Med Chem. 2010. PMID: 19908840 Free PMC article.

9

Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.

Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, Maloney DJ. Mott BT, et al. Among authors: simeonov a. J Med Chem. 2010 Jan 14;53(1):52-60. doi: 10.1021/jm901069a. J Med Chem. 2010. PMID: 19908842 Free PMC article.

10

A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase.

Yasgar A, Foley TL, Jadhav A, Inglese J, Burkart MD, Simeonov A. Yasgar A, et al. Among authors: simeonov a. Mol Biosyst. 2010 Feb;6(2):365-75. doi: 10.1039/b913291k. Epub 2009 Oct 13. Mol Biosyst. 2010. PMID: 20094656 Free PMC article.

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