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Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia.
Debenham JS, Madsen-Duggan C, Clements MJ, Walsh TF, Kuethe JT, Reibarkh M, Salowe SP, Sonatore LM, Hajdu R, Milligan JA, Visco DM, Zhou D, Lingham RB, Stickens D, DeMartino JA, Tong X, Wolff M, Pang J, Miller RR, Sherer EC, Hale JJ. Debenham JS, et al. Among authors: stickens d. J Med Chem. 2016 Dec 22;59(24):11039-11049. doi: 10.1021/acs.jmedchem.6b01242. Epub 2016 Nov 30. J Med Chem. 2016. PMID: 28002958
Discovery of Orally Bioavailable and Liver-Targeted Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PHD) Inhibitors for the Treatment of Anemia.
Liu P, Wang L, DuBois BG, Colandrea VJ, Liu R, Cai J, Du X, Quan W, Morris W, Bai J, Bishwokarma B, Cheng M, Piesvaux J, Ray K, Alpert C, Chiu CS, Zielstorff M, Metzger JM, Yang L, Leung D, Alleyne C, Vincent SH, Pucci V, Li X, Crespo A, Stickens D, Hale JJ, Ujjainwalla F, Sinz CJ. Liu P, et al. Among authors: stickens d. ACS Med Chem Lett. 2018 Nov 13;9(12):1193-1198. doi: 10.1021/acsmedchemlett.8b00274. eCollection 2018 Dec 13. ACS Med Chem Lett. 2018. PMID: 30613325 Free PMC article.
The BACH1 inhibitor ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease.
Belcher JD, Nataraja S, Abdulla F, Zhang P, Chen C, Nguyen J, Ruan C, Singh M, Demes S, Olson L, Stickens D, Stanwix J, Clarke E, Huang Y, Biddle M, Vercellotti GM. Belcher JD, et al. Among authors: stickens d. Front Med (Lausanne). 2023 Apr 18;10:1101501. doi: 10.3389/fmed.2023.1101501. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37144034 Free PMC article.
How proteases regulate bone morphogenesis.
Ortega N, Behonick D, Stickens D, Werb Z. Ortega N, et al. Among authors: stickens d. Ann N Y Acad Sci. 2003 May;995:109-16. doi: 10.1111/j.1749-6632.2003.tb03214.x. Ann N Y Acad Sci. 2003. PMID: 12814943 Review.
Metalloproteases and adipogenesis: a weighty subject.
Lilla J, Stickens D, Werb Z. Lilla J, et al. Among authors: stickens d. Am J Pathol. 2002 May;160(5):1551-4. doi: 10.1016/S0002-9440(10)61100-5. Am J Pathol. 2002. PMID: 12000705 Free PMC article. No abstract available.
17 results