Cyclophilin A contributes to aortopathy induced by postnatal loss of smooth muscle TGFBR1.
Zhou G, Liao M, Wang F, Qi X, Yang P, Berceli SA, Sharma AK, Upchurch GR Jr, Jiang Z.
Zhou G, et al.
FASEB J. 2019 Oct;33(10):11396-11410. doi: 10.1096/fj.201900601RR. Epub 2019 Jul 16.
FASEB J. 2019.
PMID: 31311317
Free PMC article.
Collectively, these results suggest a novel mechanism, wherein loss of type I receptor of TGF-beta triggers promiscuous, proinflammatory TGFBR2 signaling in SMCs, thereby promoting AAD formation.-Zhou, G., Liao, M., Wang, F., Qi, X., Yang, P., Berceli, S. A., Sharma …
Collectively, these results suggest a novel mechanism, wherein loss of type I receptor of TGF-beta triggers promiscuous, proinflammatory TGF …