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NK cell development in bone marrow and liver: site matters.
Gotthardt D, Prchal-Murphy M, Seillet C, Glasner A, Mandelboim O, Carotta S, Sexl V, Putz EM. Gotthardt D, et al. Genes Immun. 2014 Dec;15(8):584-7. doi: 10.1038/gene.2014.55. Epub 2014 Oct 16. Genes Immun. 2014. PMID: 25319498
In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity.
Prchal-Murphy M, Witalisz-Siepracka A, Bednarik KT, Putz EM, Gotthardt D, Meissl K, Sexl V, Müller M, Strobl B. Prchal-Murphy M, et al. Oncoimmunology. 2015 May 26;4(11):e1047579. doi: 10.1080/2162402X.2015.1047579. eCollection 2015 Nov. Oncoimmunology. 2015. PMID: 26451322 Free PMC article.
STAT5 Is a Key Regulator in NK Cells and Acts as a Molecular Switch from Tumor Surveillance to Tumor Promotion.
Gotthardt D, Putz EM, Grundschober E, Prchal-Murphy M, Straka E, Kudweis P, Heller G, Bago-Horvath Z, Witalisz-Siepracka A, Cumaraswamy AA, Gunning PT, Strobl B, Müller M, Moriggl R, Stockmann C, Sexl V. Gotthardt D, et al. Cancer Discov. 2016 Apr;6(4):414-29. doi: 10.1158/2159-8290.CD-15-0732. Epub 2016 Feb 12. Cancer Discov. 2016. PMID: 26873347
NK Cell-Specific CDK8 Deletion Enhances Antitumor Responses.
Witalisz-Siepracka A, Gotthardt D, Prchal-Murphy M, Didara Z, Menzl I, Prinz D, Edlinger L, Putz EM, Sexl V. Witalisz-Siepracka A, et al. Cancer Immunol Res. 2018 Apr;6(4):458-466. doi: 10.1158/2326-6066.CIR-17-0183. Epub 2018 Jan 31. Cancer Immunol Res. 2018. PMID: 29386186
Novel non-canonical role of STAT1 in Natural Killer cell cytotoxicity.
Putz EM, Majoros A, Gotthardt D, Prchal-Murphy M, Zebedin-Brandl EM, Fux DA, Schlattl A, Schreiber RD, Carotta S, Müller M, Gerner C, Decker T, Sexl V. Putz EM, et al. Oncoimmunology. 2016 May 19;5(9):e1186314. doi: 10.1080/2162402X.2016.1186314. eCollection 2016. Oncoimmunology. 2016. PMID: 27757297 Free PMC article.
Targeting PI3Kδ: One man's meat is another man's poison.
Prchal-Murphy M, Putz EM, Freissmuth M, Sexl V, Zebedin-Brandl E. Prchal-Murphy M, et al. Oncoimmunology. 2013 Jan 1;2(1):e22272. doi: 10.4161/onci.22272. Oncoimmunology. 2013. PMID: 23482629 Free PMC article.
PI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes.
Putz EM, Prchal-Murphy M, Simma OA, Forster F, Koenig X, Stockinger H, Piekorz RP, Freissmuth M, Müller M, Sexl V, Zebedin-Brandl E. Putz EM, et al. PLoS One. 2012;7(7):e40852. doi: 10.1371/journal.pone.0040852. Epub 2012 Jul 13. PLoS One. 2012. PMID: 22808277 Free PMC article.
Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice.
Pathria P, Gotthardt D, Prchal-Murphy M, Putz EM, Holcmann M, Schlederer M, Grabner B, Crncec I, Svinka J, Musteanu M, Hoffmann T, Filipits M, Berger W, Poli V, Kenner L, Bilban M, Casanova E, Müller M, Strobl B, Bayer E, Mohr T, Sexl V, Eferl R. Pathria P, et al. Oncoimmunology. 2015 Jan 22;4(4):e998529. doi: 10.1080/2162402X.2014.998529. eCollection 2015 Apr. Oncoimmunology. 2015. PMID: 26137415 Free PMC article.
38 results