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CRFR1 activation protects against cytokine-induced β-cell death.
Blaabjerg L, Christensen GL, Matsumoto M, van der Meulen T, Huising MO, Billestrup N, Vale WW. Blaabjerg L, et al. Among authors: billestrup n. J Mol Endocrinol. 2014 Dec;53(3):417-27. doi: 10.1530/JME-14-0056. Epub 2014 Oct 16. J Mol Endocrinol. 2014. PMID: 25324488 Free PMC article.
Inhibition of beta cell growth and function by bone morphogenetic proteins.
Bruun C, Christensen GL, Jacobsen ML, Kanstrup MB, Jensen PR, Fjordvang H, Mandrup-Poulsen T, Billestrup N. Bruun C, et al. Among authors: billestrup n. Diabetologia. 2014 Dec;57(12):2546-54. doi: 10.1007/s00125-014-3384-8. Epub 2014 Sep 27. Diabetologia. 2014. PMID: 25260823
Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1β is associated with changes in expression of beta-cell maturity genes and associated histone modifications.
Ibarra Urizar A, Prause M, Wortham M, Sui Y, Thams P, Sander M, Christensen GL, Billestrup N. Ibarra Urizar A, et al. Among authors: billestrup n. Mol Cell Endocrinol. 2019 Oct 1;496:110524. doi: 10.1016/j.mce.2019.110524. Epub 2019 Jul 27. Mol Cell Endocrinol. 2019. PMID: 31362031 Review.
Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.
Grunnet LG, Aikin R, Tonnesen MF, Paraskevas S, Blaabjerg L, Størling J, Rosenberg L, Billestrup N, Maysinger D, Mandrup-Poulsen T. Grunnet LG, et al. Among authors: billestrup n. Diabetes. 2009 Aug;58(8):1807-15. doi: 10.2337/db08-0178. Epub 2009 May 26. Diabetes. 2009. PMID: 19470609 Free PMC article.
Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection.
Christensen DP, Gysemans C, Lundh M, Dahllöf MS, Noesgaard D, Schmidt SF, Mandrup S, Birkbak N, Workman CT, Piemonti L, Blaabjerg L, Monzani V, Fossati G, Mascagni P, Paraskevas S, Aikin RA, Billestrup N, Grunnet LG, Dinarello CA, Mathieu C, Mandrup-Poulsen T. Christensen DP, et al. Among authors: billestrup n. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1055-9. doi: 10.1073/pnas.1320850111. Epub 2014 Jan 6. Proc Natl Acad Sci U S A. 2014. PMID: 24395784 Free PMC article.
Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents.
Christensen GL, Jacobsen ML, Wendt A, Mollet IG, Friberg J, Frederiksen KS, Meyer M, Bruun C, Eliasson L, Billestrup N. Christensen GL, et al. Among authors: billestrup n. Diabetologia. 2015 Jun;58(6):1282-90. doi: 10.1007/s00125-015-3568-x. Epub 2015 Apr 2. Diabetologia. 2015. PMID: 25828920
125 results