Scammells PJ - Search Results

1

Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.

Abdul-Ridha A, Lane JR, Mistry SN, López L, Sexton PM, Scammells PJ, Christopoulos A, Canals M. Abdul-Ridha A, et al. Among authors: scammells pj. J Biol Chem. 2014 Nov 28;289(48):33701-11. doi: 10.1074/jbc.M114.604967. Epub 2014 Oct 17. J Biol Chem. 2014. PMID: 25326383 Free PMC article.

2

2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers.

Nikolakopoulos G, Figler H, Linden J, Scammells PJ. Nikolakopoulos G, et al. Among authors: scammells pj. Bioorg Med Chem. 2006 Apr 1;14(7):2358-65. doi: 10.1016/j.bmc.2005.11.018. Epub 2005 Nov 28. Bioorg Med Chem. 2006. PMID: 16314104

3

On the stability of 2-aminoselenophene-3-carboxylates: potential dual-acting selenium-containing allosteric enhancers of A1 adenosine receptor binding.

Aumann KM, Scammells PJ, White JM, Schiesser CH. Aumann KM, et al. Among authors: scammells pj. Org Biomol Chem. 2007 Apr 21;5(8):1276-81. doi: 10.1039/b700812k. Epub 2007 Mar 15. Org Biomol Chem. 2007. PMID: 17406727

4

Structure-activity relationships of adenosines with heterocyclic N6-substituents.

Ashton TD, Aumann KM, Baker SP, Schiesser CH, Scammells PJ. Ashton TD, et al. Among authors: scammells pj. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6779-84. doi: 10.1016/j.bmcl.2007.10.028. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 17967536

5

5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers.

Aurelio L, Figler H, Flynn BL, Linden J, Scammells PJ. Aurelio L, et al. Among authors: scammells pj. Bioorg Med Chem. 2008 Feb 1;16(3):1319-27. doi: 10.1016/j.bmc.2007.10.065. Epub 2007 Oct 23. Bioorg Med Chem. 2008. PMID: 17980606

6

A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.

Valant C, Gregory KJ, Hall NE, Scammells PJ, Lew MJ, Sexton PM, Christopoulos A. Valant C, et al. Among authors: scammells pj. J Biol Chem. 2008 Oct 24;283(43):29312-21. doi: 10.1074/jbc.M803801200. Epub 2008 Aug 22. J Biol Chem. 2008. PMID: 18723515 Free PMC article.

7

2-aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists.

Ferguson GN, Valant C, Horne J, Figler H, Flynn BL, Linden J, Chalmers DK, Sexton PM, Christopoulos A, Scammells PJ. Ferguson GN, et al. Among authors: scammells pj. J Med Chem. 2008 Oct 9;51(19):6165-72. doi: 10.1021/jm800557d. Epub 2008 Sep 5. J Med Chem. 2008. PMID: 18771255 Free PMC article.

8

Synthesis of bivalent beta2-adrenergic and adenosine A1 receptor ligands.

Karellas P, McNaughton M, Baker SP, Scammells PJ. Karellas P, et al. Among authors: scammells pj. J Med Chem. 2008 Oct 9;51(19):6128-37. doi: 10.1021/jm800613s. Epub 2008 Sep 11. J Med Chem. 2008. PMID: 18783211

9

Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1).

El-Kabbani O, Scammells PJ, Gosling J, Dhagat U, Endo S, Matsunaga T, Soda M, Hara A. El-Kabbani O, et al. Among authors: scammells pj. J Med Chem. 2009 May 28;52(10):3259-64. doi: 10.1021/jm9001633. J Med Chem. 2009. PMID: 19397269

10

Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes.

Aurelio L, Valant C, Flynn BL, Sexton PM, Christopoulos A, Scammells PJ. Aurelio L, et al. Among authors: scammells pj. J Med Chem. 2009 Jul 23;52(14):4543-7. doi: 10.1021/jm9002582. J Med Chem. 2009. PMID: 19514747

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