Lear MJ - Search Results

1

Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay.

Loh CC, Suwanarusk R, Lee YQ, Chan KW, Choy KY, Rénia L, Russell B, Lear MJ, Nosten FH, Tan KS, Chow LM. Loh CC, et al. Among authors: lear mj. PLoS One. 2014 Oct 24;9(10):e110800. doi: 10.1371/journal.pone.0110800. eCollection 2014. PLoS One. 2014. PMID: 25343249 Free PMC article.

2

A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases.

Ch'ng JH, Kotturi SR, Chong AG, Lear MJ, Tan KS. Ch'ng JH, et al. Among authors: lear mj. Cell Death Dis. 2010;1(2):e26. doi: 10.1038/cddis.2010.2. Cell Death Dis. 2010. PMID: 21364634 Free PMC article.

3

A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria.

Ch'ng JH, Mok S, Bozdech Z, Lear MJ, Boudhar A, Russell B, Nosten F, Tan KS. Ch'ng JH, et al. Among authors: lear mj. Sci Rep. 2013;3:1734. doi: 10.1038/srep01734. Sci Rep. 2013. PMID: 23615863 Free PMC article.

4

Absolute configuration and total synthesis of a novel antimalarial lipopeptide by the de novo preparation of chiral nonproteinogenic amino acids.

Ghosh SK, Somanadhan B, Tan KS, Butler MS, Lear MJ. Ghosh SK, et al. Among authors: lear mj. Org Lett. 2012 Mar 16;14(6):1560-3. doi: 10.1021/ol300293a. Epub 2012 Mar 5. Org Lett. 2012. PMID: 22390733

5

Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti Trypanosoma brucei agent.

Yang PY, Wang M, Liu K, Ngai MH, Sheriff O, Lear MJ, Sze SK, He CY, Yao SQ. Yang PY, et al. Among authors: lear mj. Chemistry. 2012 Jul 2;18(27):8403-13. doi: 10.1002/chem.201200482. Epub 2012 Jun 1. Chemistry. 2012. PMID: 22674877

6

Activity-based proteome profiling of potential cellular targets of Orlistat--an FDA-approved drug with anti-tumor activities.

Yang PY, Liu K, Ngai MH, Lear MJ, Wenk MR, Yao SQ. Yang PY, et al. Among authors: lear mj. J Am Chem Soc. 2010 Jan 20;132(2):656-66. doi: 10.1021/ja907716f. J Am Chem Soc. 2010. PMID: 20028024

7

Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2.

Somanadhan B, Kotturi SR, Yan Leong C, Glover RP, Huang Y, Flotow H, Buss AD, Lear MJ, Butler MS. Somanadhan B, et al. Among authors: lear mj. J Antibiot (Tokyo). 2013 May;66(5):259-64. doi: 10.1038/ja.2012.123. Epub 2013 Jan 23. J Antibiot (Tokyo). 2013. PMID: 23340660

8

A bismuth(III)-catalyzed Friedel-Crafts cyclization and stereocontrolled organocatalytic approach to (-)-platensimycin.

Eey ST, Lear MJ. Eey ST, et al. Among authors: lear mj. Org Lett. 2010 Dec 3;12(23):5510-3. doi: 10.1021/ol102390t. Epub 2010 Oct 29. Org Lett. 2010. PMID: 21033748

9

Efficient construction of the kedarcidin chromophore ansamacrolide.

Koyama Y, Lear MJ, Yoshimura F, Ohashi I, Mashimo T, Hirama M. Koyama Y, et al. Among authors: lear mj. Org Lett. 2005 Jan 20;7(2):267-70. doi: 10.1021/ol0477374. Org Lett. 2005. PMID: 15646974

10

Total synthesis confirms laetirobin as a formal Diels-Alder adduct.

Simon O, Reux B, La Clair JJ, Lear MJ. Simon O, et al. Among authors: lear mj. Chem Asian J. 2010 Feb 1;5(2):342-51. doi: 10.1002/asia.200900306. Chem Asian J. 2010. PMID: 20033979

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