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Peripherally cross-linking the shell of core-shell polymer micelles decreases premature release of physically loaded combretastatin A4 in whole blood and increases its mean residence time and subsequent potency against primary murine breast tumors after IV administration.
Wakaskar RR, Bathena SP, Tallapaka SB, Ambardekar VV, Gautam N, Thakare R, Simet SM, Curran SM, Singh RK, Dong Y, Vetro JA. Wakaskar RR, et al. Among authors: bathena sp. Pharm Res. 2015 Mar;32(3):1028-44. doi: 10.1007/s11095-014-1515-z. Epub 2014 Sep 16. Pharm Res. 2015. PMID: 25223962 Free PMC article.
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