Edginton AN - Search Results

1

Physiologically based pharmacokinetic modeling and simulation in pediatric drug development.

Maharaj AR, Edginton AN. Maharaj AR, et al. Among authors: edginton an. CPT Pharmacometrics Syst Pharmacol. 2014 Oct 22;3(11):e150. doi: 10.1038/psp.2014.45. CPT Pharmacometrics Syst Pharmacol. 2014. PMID: 25353188 Free PMC article.

2

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development.

Edginton AN, Theil FP, Schmitt W, Willmann S. Edginton AN, et al. Expert Opin Drug Metab Toxicol. 2008 Sep;4(9):1143-52. doi: 10.1517/17425255.4.9.1143. Expert Opin Drug Metab Toxicol. 2008. PMID: 18721109 Review.

3

Simulation of differential drug pharmacokinetics under heat and exercise stress using a physiologically based pharmacokinetic modeling approach.

Sidhu P, Peng HT, Cheung B, Edginton A. Sidhu P, et al. Can J Physiol Pharmacol. 2011 May;89(5):365-82. doi: 10.1139/y11-030. Epub 2011 May 31. Can J Physiol Pharmacol. 2011. PMID: 21627485

4

A workflow example of PBPK modeling to support pediatric research and development: case study with lorazepam.

Maharaj AR, Barrett JS, Edginton AN. Maharaj AR, et al. Among authors: edginton an. AAPS J. 2013 Apr;15(2):455-64. doi: 10.1208/s12248-013-9451-0. Epub 2013 Jan 24. AAPS J. 2013. PMID: 23344790 Free PMC article.

5

Investigation of an alternative generic model for predicting pharmacokinetic changes during physiological stress.

Peng HT, Edginton AN, Cheung B. Peng HT, et al. Among authors: edginton an. J Clin Pharmacol. 2013 Oct;53(10):1048-57. doi: 10.1002/jcph.131. Epub 2013 Jul 12. J Clin Pharmacol. 2013. PMID: 23852614

6

Parameterization of small intestinal water volume using PBPK modeling.

Maharaj A, Fotaki N, Edginton A. Maharaj A, et al. Eur J Pharm Sci. 2015 Jan 25;67:55-64. doi: 10.1016/j.ejps.2014.10.016. Epub 2014 Nov 6. Eur J Pharm Sci. 2015. PMID: 25444844

7

Predicting neonatal pharmacokinetics from prior data using population pharmacokinetic modeling.

Wang J, Edginton AN, Avant D, Burckart GJ. Wang J, et al. Among authors: edginton an. J Clin Pharmacol. 2015 Oct;55(10):1175-83. doi: 10.1002/jcph.524. Epub 2015 Jun 9. J Clin Pharmacol. 2015. PMID: 25907280

8

Assessment of Age-Related Changes in Pediatric Gastrointestinal Solubility.

Maharaj AR, Edginton AN, Fotaki N. Maharaj AR, et al. Among authors: edginton an. Pharm Res. 2016 Jan;33(1):52-71. doi: 10.1007/s11095-015-1762-7. Epub 2015 Jul 29. Pharm Res. 2016. PMID: 26220249

9

Examining Small Intestinal Transit Time as a Function of Age: Is There Evidence to Support Age-Dependent Differences among Children?

Maharaj AR, Edginton AN. Maharaj AR, et al. Among authors: edginton an. Drug Metab Dispos. 2016 Jul;44(7):1080-9. doi: 10.1124/dmd.115.068700. Epub 2016 Mar 14. Drug Metab Dispos. 2016. PMID: 26977099 Review.

10

Sorafenib metabolism, transport, and enterohepatic recycling: physiologically based modeling and simulation in mice.

Edginton AN, Zimmerman EI, Vasilyeva A, Baker SD, Panetta JC. Edginton AN, et al. Cancer Chemother Pharmacol. 2016 May;77(5):1039-52. doi: 10.1007/s00280-016-3018-6. Epub 2016 Apr 6. Cancer Chemother Pharmacol. 2016. PMID: 27053087 Free PMC article.

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